Anti-CD33 (clone hP67.6)-AcBut-Calicheamicin ADC (CAT#: ADC-007LZY)

• Antibody Overview
• Humanized Anti-CD33 IgG4κ,hP67.6

• Clone
• hP676

• Antibody Isotype
• IgG4κ

• Linker
• AcBut (4-(4-acetylphenoxy)butanoic acid)

• Linker Class/Description
• Class: Chemically cleavable Linker-Acid-labile linker
  Description: Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3–7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0–6.5) and lysosomal (pH 4.5–5.0) compartments of the cell.

• Drug
• Calicheamicin

• Drug Class/Description
• Class: Calicheamicin
  Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

• Introduction
• CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

• Alternative Names
• CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;

• Gene ID
• 945

• UniProt ID
• P20138

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