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ACVR1C

Anti-ACVR1C Products
- Human Anti-ACVR1C Recombinant Antibody (HPAB-N0009-YC) (HPAB-N0009-YC)
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- Species Reactivity: Human
- Type: Human IgG
- Application: Inhib
- Human Anti-ACVR1C Recombinant Antibody; scFv Fragment (HPAB-N0009-YC-S(P)) (HPAB-N0009-YC-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: Inhib
- Human Anti-ACVR1C Recombinant Antibody; Fab Fragment (HPAB-N0009-YC-F(E)) (HPAB-N0009-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: Inhib
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For Research Use Only. Not For Clinical Use.
Background
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Leydig cells, Excitatory neurons, Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (ASC diff, HDLM-2)
Interaction
Binds the type 2 receptor protein ACVR2A.
Molecular function
Kinase, Receptor, Serine/threonine-protein kinase, Transferase
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