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ACVR1C

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For Research Use Only. Not For Clinical Use.


Background

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Leydig cells, Excitatory neurons, Proximal enterocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (ASC diff, HDLM-2)

Interaction

Binds the type 2 receptor protein ACVR2A.

Molecular function

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

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