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Target
Application
Host
Type
Species Reactivity
Conjugate
Derivation
BGN
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication.
Protein class
Disease related genes, Human disease related genes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Sertoli cells, Peritubular cells, Smooth muscle cells, Hepatic stellate cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced
Interaction
Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity).
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