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    CXCR3

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4.
    Protein class

    CD markers, G-protein coupled receptors

    Predicted location

    Membrane

    Single cell type specificity

    Cell type enhanced (dendritic cells, T-cells, Plasma cells, Proximal enterocytes, NK-cells)

    Immune cell specificity

    Immune cell enhanced (plasmacytoid DC)

    Cell line specificity

    Cell line enriched (RPMI-8226)

    Interaction

    Homomer. Forms heteromers with ACKR4.

    Molecular function

    G-protein coupled receptor, Receptor, Transducer

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