+ Filter



FCN1

Anti-FCN1 ProductsBackground
Anti-FCN1 Products
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
Background
The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.
Protein class
Plasma proteins
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Group enriched (monocytes, Macrophages, Kupffer cells)
Immune cell specificity
Immune cell enhanced (classical monocyte, intermediate monocyte)
Cell line specificity
Group enriched (NB-4, U-937)
Interaction
Homotrimer (PubMed:17897951). Interacts with elastin/ELN. Interacts (via Fibrinogen C-terminal domain) with FFAR2. Interacts with CRP; may regulate monocyte activation by FCN1.
More Types Infomation