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KLRG1
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Anti-KLRG1 Products
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For Research Use Only. Not For Clinical Use.
Background
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules.
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (NK-cells, granulocytes, T-cells, dendritic cells)
Immune cell specificity
Immune cell enhanced (MAIT T-cell, gdT-cell)
Cell line specificity
Cell line enhanced (HEL, NTERA-2, U-937)
Interaction
Forms a monomer and homodimer; disulfide-linked. Interacts (via ITIM motif) with PTPN11 and INPP5D.
Molecular function
Receptor
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