Anti-MST1R (clone e01h6) Recombinant Antibody Coupled Liposome (VS-1024-FY238) (CAT#: VS-1024-FY238)

• Potential Clinical Applications
• Pancreatic cancer

• Clone
• e01h6

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• The antibody in question is a recombinant mouse monoclonal antibody that was specifically engineered to target and bind to the Ron protein. This precise design allows for enhanced specificity and binding affinity, making it a valuable tool for research and therapeutic applications related to Ron. By focusing on this particular target, the antibody can help elucidate the biological functions of Ron and its implications in various diseases, leading to potential advancements in targeted treatments.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• MST1R

• Introduction
• Macrophage stimulating 1 receptor (MST1R) is a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.

• Alternative Names
• CD136; CDw136; NPCA3; PTK8; RON

• Full Name
• Macrophage Stimulating 1 Receptor

• Gene ID
• 4486

• UniProt ID
• Q04912

• Sequence Similarities
• Belongs to the protein kinase superfamily.

• Cellular Localization
• Membrane

• Post Translation Modifications
• Proteolytic processing yields the two subunits. ( Q04912-RON_HUMAN )
  Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site. ( Q04912-RON_HUMAN )
  Ubiquitinated.

• Protein Refseq
• XP_005265227.2; XP_011532041.1; XP_011532042.1; XP_011532043.1; XP_011532044.1

• Function
• Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand.
  Regulates many physiological processes including cell survival, migration and differentiation.
  Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules.
  Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1.
  Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.

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