Anti-MST1R (clone e01h6) Recombinant Antibody Coupled Liposome (VS-1024-FY238)
CAT#: VS-1024-FY238
Anti-Ron antibody conjugated liposomes hold significant potential in pancreatic cancer research by enabling targeted delivery of therapeutic agents specifically to tumor cells expressing the Ron receptor. This targeted approach can enhance the efficacy of chemotherapy while minimizing off-target effects, thereby improving patient outcomes. Additionally, these liposomes can be engineered to encapsulate diagnostic agents, allowing for simultaneous imaging and treatment, a strategy known as theranostics. Ultimately, the use of anti-Ron antibody conjugated liposomes may pave the way for more personalized and effective treatment strategies in pancreatic cancer management.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/44_E6_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_6_6.jpg
Normal Tissue
Figure 7 Skin
Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_B_8_1.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8180/22751_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, HBEC3-KT, hTCEpi, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000164078-MST1R
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More Infomation
Specifications
- Potential Clinical Applications
- Pancreatic cancer
Product Composition
- Clone
- e01h6
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The antibody in question is a recombinant mouse monoclonal antibody that was specifically engineered to target and bind to the Ron protein. This precise design allows for enhanced specificity and binding affinity, making it a valuable tool for research and therapeutic applications related to Ron. By focusing on this particular target, the antibody can help elucidate the biological functions of Ron and its implications in various diseases, leading to potential advancements in targeted treatments.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MST1R
- Introduction
- Macrophage stimulating 1 receptor (MST1R) is a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
- Alternative Names
- CD136; CDw136; NPCA3; PTK8; RON
- Full Name
- Macrophage Stimulating 1 Receptor
- Gene ID
- 4486
- UniProt ID
- Q04912
- Sequence Similarities
- Belongs to the protein kinase superfamily.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Proteolytic processing yields the two subunits. ( Q04912-RON_HUMAN )
Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site. ( Q04912-RON_HUMAN )
Ubiquitinated.
- Protein Refseq
- XP_005265227.2; XP_011532041.1; XP_011532042.1; XP_011532043.1; XP_011532044.1
- Function
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand.
Regulates many physiological processes including cell survival, migration and differentiation.
Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules.
Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1.
Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.
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Datasheet
MSDS
COA
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|---|---|---|---|
| TAB-184 | Anti-Human RON Recombinant Antibody (Narnatumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-332CT-S(P) | Anti-Human RON Recombinant Antibody scFv Fragment (TAB-332CT-S(P)) | WB, ELISA, FC | Human antibody |
| TAB-333CT-S(P) | Human Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-333CT-S(P)) | WB, ELISA, FC, IP | Human scFv |
| TAB-332CT-F(E) | Anti-Human RON Recombinant Antibody Fab Fragment (TAB-332CT-F(E)) | WB, ELISA, FC | Human antibody |
| TAB-333CT-F(E) | Human Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-333CT-F(E)) | WB, ELISA, FC, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-331CT-S(P) | Anti-Human RON Recombinant Antibody scFv Fragment (TAB-331CT-S(P)) | WB, ELISA, FC | |
| TAB-334CT-S(P) | Mouse Anti-MST1R Recombinant Antibody; scFv Fragment (TAB-334CT-S(P)) | WB, ELISA, FC, IP | Mouse scFv |
| TAB-331CT-F(E) | Anti-Human RON Recombinant Antibody Fab Fragment (TAB-331CT-F(E)) | WB, ELISA, FC | |
| TAB-334CT-F(E) | Mouse Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-334CT-F(E)) | WB, ELISA, FC, IP | Mouse Fab |
| TAB-335CT-F(E) | Mouse Anti-MST1R Recombinant Antibody; Fab Fragment (TAB-335CT-F(E)) | WB, ELISA, FC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1756CQ | Recombinant Mouse Anti-MST1R Antibody (CBL312) | BL | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1757CQ | Recombinant Mouse Anti-MST1R Antibody (MM0478-10F24) | Neut | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2309 | Hi-Affi™ Recombinant Rabbit Anti-MST1R Monoclonal Antibody (DS2309AB) | FC, ICC, IF, IHC-P, IP, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0062-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07923); Fab Fragment | IP, ELISA, FC | Human Fab |
| HPAB-0063-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07924); Fab Fragment | IP, ELISA, FC | Human Fab |
| HPAB-0064-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07925); Fab Fragment | IP, ELISA, FC | Human Fab |
| HPAB-0821-CN-F(E) | Human Anti-MST1R Recombinant Antibody (clone MOR07692); Fab Fragment | WB, ELISA, FC | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0135-FY-S(P) | Human Anti-MST1R Recombinant Antibody (clone sh29B06-78); scFv Fragment | WB | Humanized scFv |
| HPAB-0265CQ-S(P) | Human Anti-MST1R Recombinant Antibody (clone IMC-41A2); scFv Fragment | ELISA, WB, FC, IP | Human scFv |
| HPAB-0706-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone AB005); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0720-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody (clone AB034); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1589-FY-F(E) | Mouse Anti-MST1R Recombinant Antibody Fab Fragment (HPAB-1589-FY-F(E)) | WB, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-687-FY | Mouse Anti-MST1R Recombinant Antibody (clone 07F01) | Neut, Inhib, Cyt, ELISA | Mouse IgG |
| HPAB-688-FY | Mouse Anti-MST1R Recombinant Antibody (clone 29B06) | Neut, Inhib, ELISA | Mouse IgG |
| HPAB-689-FY | Mouse Anti-MST1R Recombinant Antibody (clone 18H09) | Neut, Inhib | Mouse IgG |
| HPAB-690-FY | Human Anti-MST1R Recombinant Antibody (clone Sh07F01-2) | Block | Chimeric (mouse/human) IgG1 |
| HPAB-N0183-YC | Mouse Anti-MST1R Recombinant Antibody (HPAB-N0183-YC) | ELISA, IF, IHC, FC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-184 | Afuco™ Anti-MST1R ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-184) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY190 | AbPlus™ Anti-MST1R Magnetic Beads (MOR07923) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY152 | Human Anti-MST1R (clone M93-D02) scFv-Fc Chimera | WB, ELISA, FC, IP | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
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| VS-0425-YC486 | Recombinant Anti-MST1R Vesicular Antibody, EV Displayed (VS-0425-YC486) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
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