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MUC17
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
Protein class
Cancer-related genes
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.
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