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SLC6A4
Loading...Anti-SLC6A4 Recombinant Antibody Products
- Mouse Anti-SLC6A4 Recombinant Antibody (clone 15B8); Fab fragment (PABJ-0101-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Rabbit Anti-SLC6A4 Recombinant Antibody (VS-0223-WK61) (VS-0223-WK61)
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- Derivation: Rabbit
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: IHC, IHC-P
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- Mouse Anti-SLC6A4 Recombinant Antibody (clone 15B8); scFv Fragment (PABJ-0101-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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For Research Use Only. Not For Clinical Use.
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
Protein class
FDA approved drug targets, Human disease related genes, Metabolic proteins, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Cytotrophoblasts, Syncytiotrophoblasts, Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BEWO, CACO-2, Hep G2)
Interaction
Monomer or homooligomer (By similarity). Interacts with TGFB1I1 (PubMed:16803896). Interacts with SEC23A, SEC24C and PATJ. Interacts with NOS1; the interaction may diminish the cell surface localization of SERT in the brain and, correspondingly, reduce serotonin reuptake. Interacts with filamentous actin and STX1A (By similarity). Interacts (via C-terminus) with SCAMP2; the interaction is direct and retains transporter molecules intracellularly (PubMed:16870614). Interacts with ITGAV:ITGB3 (By similarity).
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