Smo

Enables oxysterol binding activity; protein kinase A catalytic subunit binding activity; and protein sequestering activity. Involved in several processes, including regionalization; regulation of animal organ morphogenesis; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including nervous system development; positive regulation of cell population proliferation; and regionalization. Located in several cellular components, including centriole; ciliary membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is active in Golgi apparatus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; genitourinary system; and skeleton. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; malignant pleural mesothelioma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor).