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Target
Application
Host
Type
Species Reactivity
Expression Host
Conjugate
Derivation
TCN2
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Kupffer cells, Hepatic stellate cells, Proximal tubular cells, Adipocytes)
Immune cell specificity
Group enriched (intermediate monocyte, classical monocyte, non-classical monocyte)
Cell line specificity
Cell line enhanced (ASC TERT1, HUVEC TERT2, Karpas-707, RPTEC TERT1, TIME)
Interaction
Interacts with CD320 (via LDL-receptor class A domains).
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