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TNFSF12

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For Research Use Only. Not For Clinical Use.


Background

Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
TNFSF12
Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Adipocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (ASC TERT1, BJ hTERT+, HDLM-2)

Interaction

Homotrimer (Probable). Interacts with the angiogenic factor AGGF1/VG5Q.

Molecular function

Cytokine, Developmental protein

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