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TUBB1

Anti-TUBB1 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Macrophages)

Immune cell specificity

Group enriched (basophil, neutrophil)

Cell line specificity

Cell line enriched (HEL)

Interaction

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells. Interacts with RANBP10.

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