Anti-SLC44A4 (AGS-5)-vc-MMAE ADC
CAT#: ADC-177LCT
This ADC product is composed of an anti-SLC44A4 (AGS-5) antibody conjuagated via a vc linker to MMAE (AGS-5-vc-MMAE). It has demonstrated a response in Gastric cancer; Pancreatic cancer; Prostate cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specifications
- Antibody Overview
- Human IgG2k
- Clone
- AGS-5
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease. Three transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- CTL4; NG22; TPPT; C6orf29
- Gene ID
- 80736
- UniProt ID
- Q53GD3
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