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    Anti-Human CD274 Recombinant Antibody (B50-6) (CAT#: TAB-0999CL)

    This human monoclonal antibody recognizing PD-L1 was screened by the yeast display technology. The binding affinity of this antibody was tested by SPR with a good result. It specifically binds to PD-L1 with an EC₅₀ value of 28 μg/ml in the binding kinetics detection SPR assay. In the competitive ELISA assay detecting the blocking ability of this antibody, it got an IC₅₀ value of 0.6 μg/ml. This human/mouse antibody could be constructed and produced in Fab or scFv formats and purified by affinity chromatography with a purity higher than 95%.

    Specific Inquiry
    • Size:

    • Conjugation:

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    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
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    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg
    Figure 2 IF staining of human cell line BJ
    Figure 2 IF staining of human cell line BJ
    (Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg
    Figure 3 IF staining of human cell line U-2 OS
    Figure 3 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg
    Normal Tissue
    Figure 4 Colon
    Figure 4 Colon
    (Peripheral nerve/ganglion
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg
    Figure 5 Placenta
    Figure 5 Placenta
    (Cytotrophoblasts
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Syncytiotrophoblasts - cell body
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Syncytiotrophoblasts - microvilli
    Staining:High
    Intensity: Strong)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg
    RNA Expression
    Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)
    Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274

    Specifications

    • Host Species
    • Human
    • Derivation
    • Yeast display library
    • Type
    • Human antibody
    • Specificity
    • Human
    • Clone
    • B50-6
    • Applications
    • FuncS
    • Related Disease
    • Tumors associated with the use of PD-L1

    Applications

    • Application Notes
    • The antibody was validated for Functional Assay. For details, refer to Published Data.

    Target

    • Alternative Names
    • CD274; CD274 molecule; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; programmed cell death 1 ligand 1; B7 homolog 1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    CAT Product Name Application Type
    PSBL-298 Human Anti-CD274 Recombinant Antibody (clone CBLC-006); scFv Fragment WB, ELISA, FuncS Human scFv
    HPAB-0933LY-S(P) Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0933LY-S(P)) Inhib, ELISA Human scfv
    HPAB-0934LY-S(P) Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0934LY-S(P)) Inhib, ELISA Human scfv
    HPAB-0935LY-S(P) Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0935LY-S(P)) Inhib, ELISA Human scfv
    HPAB-0936LY-S(P) Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0936LY-S(P)) Inhib, ELISA Human scfv

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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