Anti-EpCAM Immunocytokine, IgG (KS-1/4)-IL12 (ACFP-SH166)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL12. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EpCAM as well as the biological activity of IL12. Fusion proteins composed of the human p35 and p40 subunits had IL12 bioactivities that were nearly as potent on human immune cells as the rIL12 standard, but were inactive on mouse cells. This Immunocytokines was designed for treating solid tumor.
Specifications
- Target
- EpCAM
- Molecule Class
- IgG1-IL12
- Species Reactivity
- Human
- Host
- Mouse
- Expression Host
- CHO
- Clone
- KS-1/4
- Related Disease
- Solid tumor
- Cytokines 1
- IL12
- Cytokines 1 Description
- Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
- Entrez Gene ID
- 4072
- UniProt ID
- P16422
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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