Anti-EpCAM Antibody-Cytokine Fusion Protein, IgG (KS-1/4)-IL12 (CAT#: ACFP-SH166)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL12. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EpCAM as well as the biological activity of IL12. Fusion proteins composed of the human p35 and p40 subunits had IL12 bioactivities that were nearly as potent on human immune cells as the rIL12 standard, but were inactive on mouse cells. This Immunocytokines was designed for treating solid tumor.

Specific Inquiry
  • Size:

  • Conjugation:

  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Target
  • EpCAM
  • Molecule Class
  • IgG1-IL12
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • KS-1/4
  • Related Disease
  • Solid tumor
  • Cytokine 1
  • IL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component; chromosome 4; surface marker (35kD glycoprotein)

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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