Anti-EpCAM Immunocytokine, IgG (KS-1/4)-IL4-GM-CSF (ACFP-SH190)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL4 and GM-CSF. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the EpCAM as well as the biological activity of IL4 and GM-CSF. The IL-4 activity and the GM-CSF activity of KS-IL4-GMCSF were similar to purified IL-4 and GM-CSF. This Immunocytokines was designed for treating solid tumor.
Specifications
- Target
- EpCAM
- Molecule Class
- IgG1-IL4-GM-CSF
- Species Reactivity
- Human
- Host
- Mouse
- Expression Host
- CHO
- Clone
- KS-1/4
- Related Disease
- Solid tumor
- Cytokines 1
- IL4
- Cytokines 1 Description
- The interleukin 4 (IL4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. The cell that initially produces IL-4, thus inducing Th0 differentiation, has not been identified, but recent studies suggest that basophils may be the effector cell. It is closely related and has functions similar to Interleukin 13.
- Cytokine 1 Species
- Human
- Cytokines 2
- GM-CSF
- Cytokines 2 Description
- Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
- Cytokine 2 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2
- Entrez Gene ID
- 4072
- UniProt ID
- P16422
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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