Anti-Human IGF-1R Recombinant Antibody (1A) (CAT#: TAB-058ZJ)
Recombinant monoclonal antibody to insulin-like growth factor 1 receptor. A6 is a human antibody that can be potentially used in the treatment of tumor and cancer.
Specific Inquiry
FC
Figure 1 IGF-1R expression was up-regulated in SKOV3-T while HER2 was opposite by flow cytometry analysis.
IGF-1R can promote the proliferation of SKOV3.
Wang, W., Zhang, Y., Lv, M., Feng, J., Peng, H., Geng, J., ... & Ma, Y. (2014). Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3. Journal of ovarian research, 7(1), 103.
WB
Figure 2 WB analysis of IGF-1R in SKOV3 cells.
IGF-1R-positive SKOV3 cell preparation by eukaryotic transfection with pCMV6-IGF-1R plasmid.
Wang, W., Zhang, Y., Lv, M., Feng, J., Peng, H., Geng, J., ... & Ma, Y. (2014). Anti-IGF-1R monoclonal antibody inhibits the carcinogenicity activity of acquired trastuzumab-resistant SKOV3. Journal of ovarian research, 7(1), 103.
Specifications
- Immunogen
- Soluble extracellular domain of IGF-IR.
- Host Species
- Human
- Type
- Human antibody
- Specificity
- Human
- Species Reactivity
- Marmoset monkey, Cynomolgus monkey, Human
- Clone
- 1A
- Applications
- FC, WB
- Related Disease
- Tumor, Cancer
Applications
- Application Notes
- The IGF1R antibody has been reported in applications of Western Blot, Flow Cytometry.FC:Cells were collected and stained with appropriate PE conjugated antibodies against membrane markers. For each sample, data from approximately 15,000 cells were analyzed using a BD-FACStar™ instrument. Data analysis (the percentage and intensity of stained cells, etc.) was performed on a FACS Calibur flow cytometer using the BD CellQuest™ program. WB:The samples were electrophoretically separated on SDS-PAGE and transferred to NC membrane. The membranes were blocked with 5% non-fat dry milk dissolved in TBST (10 mM Tris HCl, 150 mM NaCl containing 0.05% Tween 20, pH 7.4) for 1 hour before probing overnight at 4°C with the appropriate primary antibody (IGF-1R). In the second day, after washed with TBST three times, the membranes were incubated with HRP-conjugated secondary antibody for 1 hour at room temperature.
Target
- Alternative Names
- IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor
- Gene ID
- 3480
- UniProt ID
- P08069
Related Resources
Insulin Signaling Pathway
Endocrine Resistance
Type I Diabetes Mellitus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone 1A"
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-091 | Recombinant Anti-human IGF1R VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-096ZJ | Anti-Human IGF-1R Therapeutic Single Domain Antibody (IGF1 R-3) | ELISA, IHC, IF, WB | Single domain antibody |
| HPAB-1545-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (m632) | WB, ELISA | Llama VHH |
| HPAB-1546-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (m636) | WB, ELISA | Llama VHH |
| HPAB-1547-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (m546) | WB, ELISA | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-199 | Human Anti-IGF1R Recombinant Antibody (TAB-199) | FC, IP, ELISA, Neut, FuncS, IF, ICC | Human IgG1, κ |
| TAB-209 | Anti-Human IGF1 Receptor Recombinant Antibody (Robatumumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-052ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (18) | ELISA, FC, IF, IP | Human antibody |
| TAB-053ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (IR3) | ELISA, FC, WB | Human antibody |
| TAB-054ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (IR10) | ELISA, FC, WB | Human antibody |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-736 | Anti-IGF1R Recombinant Antibody (Dalotuzumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
| TAB-386CL | Humanized Anti-IGF1R Recombinant Antibody (TAB-386CL) | FuncS | Humanized IgG |
| TAB-035ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-035ZJ) | ELISA, FC | Humanized IgG |
| TAB-036ZJ | Anti-Human IGF-1R Recombinant Antibody (H0L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
| TAB-037ZJ | Anti-Human IGF-1R Recombinant Antibody (H1L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L024E | IGF1-PE immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L024D | IGF1-DT immunotoxin | Cytotoxicity assay, Functional assay |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-371CL | Afuco™ Anti-Human IGF1R Antibody, ADCC Enhanced (AFC-371CL) | ELISA | ADCC enhanced antibody |
| AFC-TAB-199 | Afuco™ Anti-IGF1R Recombinant Antibody (AFC-TAB-199), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | Human IgG1, κ |
| AFC-TAB-209 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Robatumumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-736 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Dalotuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-078 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Cixutumumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009ZJ | Mouse Anti-IGF1R Recombinant Antibody (TAB-009ZJ) | ELISA, FC | Mouse IgG1, κ |
| TAB-010ZJ | Anti-Human IGF-1R Recombinant Antibody (6E11) | ELISA, Neut, FC, IHC | |
| TAB-011ZJ | Mouse Anti-IGF1R Recombinant Antibody (TAB-011ZJ) | ELISA, FC, WB, Inhib | Mouse IgG2, κ |
| TAB-012ZJ | Mouse Anti-IGF1R Recombinant Antibody (TAB-012ZJ) | ELISA, FC, WB, Inhib | Mouse IgG2, κ |
| TAB-016ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (7C2) | IP, IHC, ELISA, FC |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-084ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-084ZJ) | WB, Inhib, ELISA, FC | Chimeric (mouse/human) IgG |
| TAB-085ZJ | Anti-Human IGF-1R Recombinant Antibody (6E11c) | ELISA, FC, IHC, Inhib | Chimeric antibody (mouse/human) |
| TAB-086ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-086ZJ) | ELISA, FC, Inhib, IP | Chimeric (mouse/human) IgG1 |
| TAB-087ZJ | Anti-Human IGF-1R Recombinant Antibody (ch7C2) | ELISA | Chimeric antibody (mouse/human) |
| TAB-093ZJ | Anti-Human IGF-1R Recombinant Antibody (ch9E11) | ELISA | Chimeric antibody (mouse/human) |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0103MZ | Chicken Anti-CD221 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1075CQ | Mouse Anti-IGF1R Recombinant Antibody (clone alphaIR3) | FC, IP, Neut, ICC, IF | Mouse IgG1 |
| NEUT-1076CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 33255.111) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1081CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL453) | WB, ELISA, Neut | Mouse IgG1 |
| NEUT-1082CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL080) | Neut, WB | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1077CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 1H7) | FC, Block, IHC, IP, WB | Mouse IgG1, κ |
| NEUT-1078CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-60) | Inhib, ICC, IF, IP, WB | Mouse IgG2a, κ |
| NEUT-1079CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 17-69) | Inhib, IP | Mouse IgG1 |
| NEUT-1080CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-57) | Inhib, IP | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1755 | Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB) | IP, ELISA | Rabbit IgG |
| MOR-4684 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH198DS) | WB, ELISA | Rabbit IgG |
| MOR-4685 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH199DS) | WB | Rabbit IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-041CN | Mouse Anti-IGF1R Recombinant Antibody (NS-041CN) | ELISA, WB, FC | Mouse IgG |
| NS-041CN-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (NS-041CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| NS-041CN-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P)) | ELISA, WB, FC | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0210CQ | Human Anti-IGF1R Recombinant Antibody (clone 15H12) | ELISA, FC, Neut | Human IgG3, κ |
| HPAB-0211CQ | Human Anti-IGF1R Recombinant Antibody (clone 1H3) | ELISA, FC, Neut | Human IgG |
| HPAB-0212CQ | Human Anti-IGF1R Recombinant Antibody (clone 11A4) | ELISA, FC, Block | Human IgG1 |
| HPAB-0213CQ | Human Anti-IGF1R Recombinant Antibody (clone 8A1) | ELISA, FC, Block | Human IgG1 |
| HPAB-0214CQ | Human Anti-IGF1R Recombinant Antibody (clone PINT-9A2) | ELISA, FC, Block | Human IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1441LY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-1441LY-S(P)) | ELISA, IHC | Human scFv |
| HPAB-1442LY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-1442LY-S(P)) | ELISA, IHC | Human scFv |
| HPAB-1277WJ-S(P) | Mouse Anti-IGF1R Recombinant Antibody (clone 1H7); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1945-FY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-1945-FY-S(P)) | Inhib | Human scFv |
| HPAB-2063-FY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-2063-FY-S(P)) | IA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1441LY-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-1441LY-F(E)) | ELISA, IHC | Humanized Fab |
| HPAB-1442LY-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-1442LY-F(E)) | ELISA, IHC | Humanized Fab |
| HPAB-0712-FY-S(P) | Mouse Anti-IGF1R Recombinant Antibody (clone AB011); Fab Fragment | FC | Mouse Fab |
| HPAB-0839-FY-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-0839-FY-S(P)) | IHC | Mouse scFv |
| HPAB-0840-FY-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-0840-FY-S(P)) | IHC | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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