Afuco™ Anti-Human IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-407CL) (CAT#: AFC-407CL)
Anti-IL2RA ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This anitbody specifically targets the TAC antigen and strongly inhibits IL-2 binding to the IL-2R and antigen-induced T cell proliferation. It is used for the treatment of acute renal transplant rejection and has been in development for the treatment of T cell leukemia, multiple sclerosis, graft-versus-host disease, ulcerative colitis, uveitis and asthma.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
Figure 2 Tonsil
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
(Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Autoimmune Diseases
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- ≤6 months at 4°C; ≥6 months at -20°C.
Target
- Alternative Names
- IL2RA; interleukin 2 receptor, alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha
- Gene ID
- 3559
- UniProt ID
- P01589
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B073(A) | Recombinant Anti-human IL2RA Intrabody [(D-Arg)9] | IF, ELISA, FuncS | scFv-(D-Arg)9 |
| IAB-B073(G) | Recombinant Anti-human IL2RA Intrabody [+36 GFP] | IF, FC, WB, FuncS | scFv-(+36GFP) |
| IAB-B073(T) | Recombinant Anti-human IL2RA Intrabody [Tat] | WB, CO-IP, FuncS | scFv-Tat |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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