Afuco™ Anti-Human IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-407CL)

Name: Afuco™ Anti-Human IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-407CL)
SKU: AFC-407CL
Rating: 5 (1 reviews)

CAT#: AFC-407CL

Anti-IL2RA ADCC Enhanced Antibody is an ADCC enhanced antibody produced by our Afuco™ platform. This anitbody specifically targets the TAC antigen and strongly inhibits IL-2 binding to the IL-2R and antigen-induced T cell proliferation. It is used for the treatment of acute renal transplant rejection and has been in development for the treatment of T cell leukemia, multiple sclerosis, graft-versus-host disease, ulcerative colitis, uveitis and asthma.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA

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Specifications

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Species Reactivity
Human

Related Disease
Autoimmune Diseases

Product Property

Purity
>95%, by SDS-PAGE, under reducing conditions

Storage
≤6 months at 4°C; ≥6 months at -20°C.

Target

Alternative Names
IL2RA; interleukin 2 receptor, alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha

Gene ID
3559

UniProt ID
P01589

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-407CL.pdf

MSDS

MSDS - AFC-407CL.pdf

COA

Certificate of Analysis Lookup

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