This immunotoxin was achieved by conjugating/fusing the IL-2 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cell leukaemia cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of T cell leukaemia.
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CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B073(A) | Recombinant Anti-human IL2RA Intrabody [(D-Arg)9] | IF, ELISA, FuncS | scFv-(D-Arg)9 |
IAB-B073(G) | Recombinant Anti-human IL2RA Intrabody [+36 GFP] | IF, FC, WB, FuncS | scFv-(+36GFP) |
IAB-B073(T) | Recombinant Anti-human IL2RA Intrabody [Tat] | WB, CO-IP, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-023 | Anti-Human CD25 Recombinant Antibody (Daclizumab) | ELISA, Neut, IF, IP, FC, FuncS | IgG1 - kappa |
TAB-652LC-S(P) | Anti-human IL2RA scFv Fragment (5G7) | ELISA | Humanized antibody |
TAB-646LC-F(E) | Anti-human IL2RA Fab Fragment (48M54S) | ELISA, FC | Humanized antibody |
TAB-647LC-F(E) | Anti-human IL2RA Fab Fragment (48M51L) | ELISA, FC | Humanized antibody |
TAB-648LC-F(E) | Anti-human IL2RA Fab Fragment (48V54S) | ELISA, FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-004 | Anti-Human CD25 Recombinant Antibody (Basiliximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
PABX-030 | Recombinant Human Anti-CD25 Antibody (SDZCHII621) | Neut, FuncS | IgG |
PABX-030-F (E) | Recombinant Mouse Anti-CD25 Antibody Fab Fragment (SDZCHII621) | Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-155 | Anti-Human CD25 Recombinant Antibody (Inolimomab) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
TAB-641LC | Anti-human IL2RA Recombinant Antibody (Inolimomab) (TAB-641LC) | ELISA | |
TAB-641LC-S(P) | Anti-human IL2RA scFv Fragment (Inolimomab) | ELISA | |
TAB-641LC-F(E) | Anti-human IL2RA Fab Fragment (Inolimomab) | ELISA | |
PABX-029-S (P) | Recombinant Human Anti-CD25 Antibody scFv Fragment (Daclizumab) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L027D | anti-IL2RA immunotoxin RFT5 (scFv)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L027R | anti-IL2RA immunotoxin RFT5 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L028E | anti-IL2RA immunotoxin RFT5 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L028D | anti-IL2RA immunotoxin RFT5 (IgG)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L028R | anti-IL2RA immunotoxin RFT5 (IgG)-RTA | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-242 | Human Anti-IL2RA Recombinant Antibody (clone 1H4); scFv Fragment | WB, IHC, FuncS | Human scFv |
PSBZ-020 | Mouse Anti-IL2RA Recombinant Antibody (clone CHI621); scFv Fragment | Block | Mouse scFv |
HPAB-0559-WJ-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0559-WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-0560-WJ-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0560-WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-1536WJ-S(P) | Rat Anti-IL2RA Recombinant Antibody; scFv Fragment (clone YTH 906.9.21) | ELISA, WB | Rat scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-242 | Human Anti-IL2RA Recombinant Antibody (clone 1H4); Fab Fragment | WB, IHC, FuncS | Human Fab |
PFBZ-020 | Human Anti-IL2RA Recombinant Antibody (clone CHI621); Fab Fragment | Block | Chimeric (mouse/human) Fab |
PFBZ-082 | Human Anti-IL2RA Recombinant Antibody (clone SDZ CHI621); Fab Fragment | Block | Chimeric (mouse/human) Fab |
HPAB-0060-FY-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0060-FY-F(E)) | ELISA | Humanized Fab |
HPAB-2113-FY-F(E) | Mouse Anti-IL2RA Recombinant Antibody (clone MAK179); Fab Fragment | Inhib | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-642LC | Human Anti-IL2RA Recombinant Antibody (TAB-642LC) | ELISA, FC, Inhib | Human IgG1, κ |
TAB-642LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-642LC-S(P)) | ELISA, FC | Human scFv |
TAB-643LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-643LC-S(P)) | ELISA, FC | Human scFv |
TAB-644LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-644LC-S(P)) | ELISA, FC | Human scFv |
TAB-645LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-645LC-S(P)) | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1344CQ | Mouse Anti-IL2RA Recombinant Antibody (clone B-B10) | FC, Neut, WB, IF | Mouse IgG1, κ |
NEUT-1345CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL017) | Neut, WB, IHC | Mouse IgG1 |
NEUT-1346CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL242) | ELISA, FC, Neut | Mouse IgG1, κ |
NEUT-1348CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL726) | WB, IHC, ICC, Neut | Mouse IgG1 |
NEUT-1349CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 1X27) | IHC, Neut, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1350CQ | Mouse Anti-IL2RA Recombinant Antibody (clone 2R12) | Block, FC, ICC, IF, IHC, IP, WB | Mouse IgG1 |
NEUT-1356CQ | Rat Anti-Il2ra Recombinant Antibody (VMC199) | FC, IP, IHC, Block, Depletion | Rat IgG1, λ |
NEUT-1357CQ | Rat Anti-Il2ra Recombinant Antibody (clone 3C7) | FC, IP, Inhib | Rat IgG2b, κ |
NEUT-1358CQ | Rat Anti-Il2ra Recombinant Antibody (clone mAb0817) | Block, Depletion | Rat IgG1 |
NEUT-1359CQ | Rat Anti-Il2ra Recombinant Antibody (clone mAb0845) | Block, FC, IHC-Fr, IP | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1808 | Rabbit Anti-IL2RA Recombinant Antibody (clone DS1808AB) | IHC, ICC, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-004 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Basiliximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-023 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Daclizumab), ADCC Enhanced | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
AFC-TAB-155 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody (Inolimomab), ADCC Enhanced | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0559-WJ | Human Anti-IL2RA Recombinant Antibody (HPAB-0559-WJ) | ELISA, Inhib, FuncS, FC | Human IgG |
HPAB-0560-WJ | Human Anti-IL2RA Recombinant Antibody (HPAB-0560-WJ) | ELISA, Inhib, FuncS, FC | Human IgG |
HPAB-0561-WJ | Human Anti-IL2RA Recombinant Antibody (HPAB-0561-WJ) | ELISA, Inhib, FuncS, FC | Human IgG |
HPAB-2113-FY | Mouse Anti-IL2RA Recombinant Antibody (clone MAK179) | Inhib | Mouse IgG |
HPAB-1536WJ | Rat Anti-IL2RA Recombinant Antibody (clone YTH 906.9.21) | ELISA, WB | Rat IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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