IL2-PE immunotoxin
CAT#: AGTO-L078E
This immunotoxin was achieved by conjugating/fusing the IL-2 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cell leukaemia cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of T cell leukaemia.



Specifications
- Host Species
- Human
- Species Reactivity
- Human
- Molecule Class
- IL2-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- T cell leukaemia
Target
- Alternative Names
- CD25; IDDM10; IL 2 RA; IL 2 receptor subunit alpha; IL 2R alpha chain; IL 2R subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2 RA; IL2 Receptor alpha; IL2 receptor subunit alpha; IL2-RA; IL2R alpha chain; IL2R; IL2R subunit alpha; IL2RA; IL2RA_HUMAN; Interleukin 2 receptor alpha chain; interleukin 2 receptor subunit alpha; Interleukin 2 receptor, alpha; Interleukin-2 receptor subunit alpha; Ly 43; Ly43; OTTHUMP00000019030; OTTHUMP00000019031; OTTHUMP00000019032; p55; p55 chain; T Cell Growth Factor Receptor; TAC antigen; TCGFR; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE35
- Gene ID
- 3559
- UniProt ID
- P01589
Customer Review
There are currently no Customer reviews or questions for AGTO-L078E. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
See other products for "IL2RA"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B073(A) | Recombinant Anti-human IL2RA Intrabody [(D-Arg)9] | IF, ELISA, FuncS | scFv-(D-Arg)9 |
IAB-B073(G) | Recombinant Anti-human IL2RA Intrabody [+36 GFP] | IF, FC, WB, FuncS | scFv-(+36GFP) |
IAB-B073(T) | Recombinant Anti-human IL2RA Intrabody [Tat] | WB, CO-IP, FuncS | scFv-Tat |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-023 | Anti-Human CD25 Recombinant Antibody (Daclizumab) | ELISA, Neut, IF, IP, FC, FuncS | IgG1 - kappa |
TAB-646LC-F(E) | Anti-human IL2RA Fab Fragment (48M54S) | ELISA, FC | Humanized antibody |
TAB-647LC-F(E) | Anti-human IL2RA Fab Fragment (48M51L) | ELISA, FC | Humanized antibody |
TAB-648LC-F(E) | Anti-human IL2RA Fab Fragment (48V54S) | ELISA, FC | Humanized antibody |
TAB-649LC-F(E) | Anti-human IL2RA Fab Fragment (Dmab) | FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-004 | Anti-Human CD25 Recombinant Antibody (Basiliximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
PABX-030 | Recombinant Human Anti-CD25 Antibody (SDZCHII621) | Neut, FuncS | IgG |
PABX-030-F (E) | Recombinant Mouse Anti-CD25 Antibody Fab Fragment (SDZCHII621) | Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-155 | Anti-Human CD25 Recombinant Antibody (TAB-155) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
TAB-641LC | Anti-human IL2RA Recombinant Antibody (TAB-641LC) | ELISA | |
TAB-641LC-S(P) | Anti-human IL2RA scFv Fragment (TAB-641LC-S(P)) | ELISA | |
TAB-641LC-F(E) | Anti-human IL2RA Fab Fragment (TAB-641LC-F(E)) | ELISA | |
PABX-029-S (P) | Recombinant Human Anti-CD25 Antibody scFv Fragment (Daclizumab) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L027D | anti-IL2RA immunotoxin RFT5 (scFv)-DT | Cytotoxicity assay, Functional assay | |
AGTO-L027R | anti-IL2RA immunotoxin RFT5 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
AGTO-L028E | anti-IL2RA immunotoxin RFT5 (IgG)-PE | Cytotoxicity assay, Functional assay | |
AGTO-L078D | IL2-DT immunotoxin | Cytotoxicity assay, Functional assay | |
AGTO-L078R | IL2-RTA immunotoxin | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-608 | Human Anti-IL2RA Recombinant Antibody (clone RTF5); Fab Fragment | WB, FuncS | Chimeric (mouse/human) Fab |
HPAB-M0454-YC-F(E) | Mouse Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-M0454-YC-F(E)) | ELISA | Mouse Fab |
HPAB-0559-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0559-WJ-F(E)) | ELISA, FC | Human Fab |
HPAB-0560-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0560-WJ-F(E)) | ELISA, FC | Human Fab |
HPAB-0561-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0561-WJ-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-082 | Mouse Anti-IL2RA Recombinant Antibody (clone SDZ CHI621); scFv Fragment | Block | Mouse scFv |
PSBL-608 | Mouse Anti-IL2RA Recombinant Antibody (clone RTF5); scFv Fragment | WB, FuncS | Mouse scFv |
HPAB-0559-WJ-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0559-WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-0560-WJ-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0560-WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-0561-WJ-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (HPAB-0561-WJ-S(P)) | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-642LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-642LC-S(P)) | ELISA, FC | Human scFv |
TAB-643LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-643LC-S(P)) | ELISA, FC | Human scFv |
TAB-644LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-644LC-S(P)) | ELISA, FC | Human scFv |
TAB-645LC-S(P) | Human Anti-IL2RA Recombinant Antibody; scFv Fragment (TAB-645LC-S(P)) | ELISA, FC | Human scFv |
PABX-029 | Recombinant Human Anti-CD25 Antibody (Daclizumab) | WB, ELISA, FuncS, FC, Cyt | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-0351MZ | Recombinant Mouse Anti-Human IL2RA Antibody (clone BCT-2) | ELISA | Mouse antibody |
FAMAB-1200CQ | Human Anti-IL2RA Recombinant Antibody (clone Anti-Tac) | CDC | Human IgG1 |
FAMAB-1201CQ | Human Anti-IL2RA Recombinant Antibody (clone AHT54) | Block, ELISA, FC | Human IgG1 |
FAMAB-1202CQ | Human Anti-IL2RA Recombinant Antibody (clone YTH 906.9HL (Campath-6)) | IP, Block, FC | Human IgG1 |
VS3-WK1456 | Mouse Anti-IL2RA Recombinant Antibody (clone 776) | FC, IF | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1344CQ | Mouse Anti-IL2RA Recombinant Antibody (clone B-B10) | FC, Neut, WB, IF | Mouse IgG1, κ |
NEUT-1345CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL017) | Neut, WB, IHC | Mouse IgG1 |
NEUT-1346CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL242) | ELISA, FC, Neut | Mouse IgG1, κ |
NEUT-1348CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL726) | WB, IHC, ICC, Neut | Mouse IgG1 |
NEUT-1349CQ | Mouse Anti-IL2RA Recombinant Antibody (NEUT-1349CQ) | IHC, Neut, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1350CQ | Mouse Anti-IL2RA Recombinant Antibody (NEUT-1350CQ) | Block, FC, ICC, IF, IHC, IP, WB | Mouse IgG1 |
NEUT-1356CQ | Rat Anti-Il2ra Recombinant Antibody (VMC199) | FC, IP, IHC, Block, Depletion | Rat IgG1, λ |
NEUT-1357CQ | Rat Anti-Il2ra Recombinant Antibody (clone 3C7) | FC, IP, Inhib | Rat IgG2b, κ |
NEUT-1358CQ | Rat Anti-Il2ra Recombinant Antibody (NEUT-1358CQ) | Block, Depletion | Rat IgG1 |
NEUT-1359CQ | Rat Anti-Il2ra Recombinant Antibody (NEUT-1359CQ) | Block, FC, IHC-Fr, IP | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1808 | Rabbit Anti-IL2RA Recombinant Antibody (clone DS1808AB) | IHC, ICC, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-004 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-004) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-023 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-023) | ELISA, Neut, IF, IP, FC, FuncS | ADCC enhanced antibody |
AFC-TAB-155 | Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-155) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0424-XY150 | AbPlus™ Anti-IL2RA Magnetic Beads (2R12) | IP, Protein Purification |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0924-YC133 | Human Anti-IL2RA Recombinant Antibody Hexamer (VS-0924-YC133), CDC Enhanced | CDC | Antibody hexamer |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0924-YC47 | Rabbit Anti-IL2RA Antibody (VS-0924-YC47) - Cancer Stem Cell Marker | IHC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0125-FY44 | Human Anti-IL2RA (clone MAK179) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
VS-0425-FY42 | Mouse Anti-IL2RA (clone mAb1) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY135 | CytoStream™ Mouse Anti-IL2RA Recombinant Antibody (clone BC96) | FC | Mouse IgG1, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC386 | Recombinant Anti-IL2RA Vesicular Antibody, EV Displayed (VS-0425-YC386) | ELISA, FC, Neut, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY3520 | Anti-IL2RA Immunohistochemistry Kit | IHC | |
VS-0525-XY3521 | Anti-Mouse IL2RA Immunohistochemistry Kit | IHC | |
VS-0525-XY3522 | Anti-Rat IL2RA Immunohistochemistry Kit | IHC |
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: FC, IHC, FuncS, Inhib, Cyt
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, IHC, FC, WB, IF, IA
Application: Block, IP, IF, FC
Application: ELISA, IHC, FC, IP, IF, BL
Application: FC, FuncS, IA, IF, IP, IHC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.