This bispecific antibody recognizing c-Met and Her3 at the same time shows an improved effect for inhibiting cancer cell compared to anti-c-Met antibody alone, by inhibiting both c-Met and Her3. The anti-c-Met/anti-Her3 bispecific antibody can also obtain efficient effects even when applied to patients who have developed resistance against pre-existing anti-Her3 antibodies. It is also capable of inhibiting the activity of c-Met and Her3 by the internalization and degradation of c-Met and Her3.
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