Recombinant Anti-MET × Anti-ErbB-3 Bispecific Antibody (Triplebody) (CAT#: TRIAB-MZ010)
This bispecific antibody recognizing c-Met and Her3 at the same time shows an improved effect for inhibiting cancer cell compared to anti-c-Met antibody alone, by inhibiting both c-Met and Her3. The anti-c-Met/anti-Her3 bispecific antibody can also obtain efficient effects even when applied to patients who have developed resistance against pre-existing anti-Her3 antibodies. It is also capable of inhibiting the activity of c-Met and Her3 by the internalization and degradation of c-Met and Her3.
Specific Inquiry
Specifications
- Target
- MET & ErbB-3
- Type
- Triplebody
- Species Reactivity
- Human
- Target 1
- MET
- Host Species 1
- Human
- Target 2
- ErbB-3
- Host Species 2
- Human
- Application
- Biacore assay, Cell proliferation assay
- Related Disease
- Stomach cancer, pancreatic cancer
Target
- Target 1
- MET
- Gene ID
- 4233
- UniProt ID
- A0A024R759
- Alternative Names
- MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
- Target 2
- ErbB-3
- Gene ID
- 2065
- UniProt ID
- P21860
- Alternative Names
- ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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