CBD scaffold protein anti-Bovine Alkaline phosphatase (CAT#: SCB-L050)
The CBD that bound Alkaline phosphatase was isolated from the library using Phage display techonology. CBD is a member of the knottin family which is a kind of small, disulphide-bonded proteins that bind with high specificity to their target molecules. After affinity maturation, CBD variants were identified having affinities (KD=10 μM) for Alkaline phosphatase as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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Normal Tissue
RNA Expression
Figure 1 Small intestine
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_4_2.jpg
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_4_2.jpg
Figure 2 Colon
(Enterocytes - Microvilli Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_8_3.jpg
(Enterocytes - Microvilli Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_8_3.jpg
Figure 3 Testis
(Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_5_6.jpg
(Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_5_6.jpg
Figure 4 RNA cell line category: Cell line enriched (CACO-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163295-ALPI
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163295-ALPI
Specifications
- Scaffold Name
- CBD
- Origin
- Fungal enzyme cellobiohydrolase I
- Core Structure
- 3β-sheet (36)
- Variable Regions
- 11 aa on loops or 7 aa on flat surface
- Target
- Alkaline phosphatase
- Species Reactivity
- Bovine
- Expression Host
- E. coli
- Affinity Constant
- 10 μM
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
- Alternative Names
- Fungal enzyme cellobiohydrolase I; CBD; HOPS; TNAP; APTNAP; TNSALP; AP-TNAP
- Gene ID
- 280993
- UniProt ID
- P19111.2
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0550MZ | Mouse Anti-ALPI Recombinant Antibody (clone BQ2C0) | IHC-Fr, IHC-P | Mouse IgG1 |
| ZG-485C | Mouse Anti-ALPI Recombinant Antibody (clone 8A8E3) | ELISA | Mouse IgG2b, κ |
| ZG-500C | Mouse Anti-ALPI Recombinant Antibody (clone 22E5.1) | ELISA | Mouse IgG1, κ |
| VS3-XY45 | Mouse Anti-ALPI Recombinant Antibody (clone 3B10E7) | ELISA, WB, FC | Mouse IgG1 |
| VS3-XY3259 | Rabbit Anti-ALPI Recombinant Antibody (clone R07-3R5) | WB, IHC-P | Rabbit IgG |
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