CBD scaffold protein anti-Bovine Alkaline phosphatase (CAT#: SCB-L050)
The CBD that bound Alkaline phosphatase was isolated from the library using Phage display techonology. CBD is a member of the knottin family which is a kind of small, disulphide-bonded proteins that bind with high specificity to their target molecules. After affinity maturation, CBD variants were identified having affinities (KD=10 μM) for Alkaline phosphatase as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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Normal Tissue
RNA Expression
Figure 1 Small intestine
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_4_2.jpg
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_4_2.jpg
Figure 2 Colon
(Enterocytes - Microvilli Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_8_3.jpg
(Enterocytes - Microvilli Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_8_3.jpg
Figure 3 Testis
(Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_5_6.jpg
(Cells in seminiferous ducts Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Leydig cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51699/138820_A_5_6.jpg
Figure 4 RNA cell line category: Cell line enriched (CACO-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163295-ALPI
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000163295-ALPI
Specifications
- Scaffold Name
- CBD
- Origin
- Fungal enzyme cellobiohydrolase I
- Core Structure
- 3β-sheet (36)
- Variable Regions
- 11 aa on loops or 7 aa on flat surface
- Target
- Alkaline phosphatase
- Species Reactivity
- Bovine
- Expression Host
- E. coli
- Affinity Constant
- 10 μM
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
- Alternative Names
- Fungal enzyme cellobiohydrolase I; CBD; HOPS; TNAP; APTNAP; TNSALP; AP-TNAP
- Gene ID
- 280993
- UniProt ID
- P19111.2
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1875z | Mouse Anti-ALPI Recombinant Antibody (clone 31A8) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| MOB-0550MZ | Mouse Anti-ALPI Recombinant Antibody (clone BQ2C0) | IHC-Fr, IHC-P | Mouse IgG1 |
| ZG-485C | Mouse Anti-ALPI Recombinant Antibody (clone 8A8E3) | ELISA | Mouse IgG2b, κ |
| ZG-500C | Mouse Anti-ALPI Recombinant Antibody (clone 22E5.1) | ELISA | Mouse IgG1, κ |
| VS3-XY3259 | Rabbit Anti-ALPI Recombinant Antibody (clone R07-3R5) | WB, IHC-P | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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