Anti-CD33 (HuM195)-AcBut-Calicheamicin ADC (CAT#: ADC-056LCT)

• Antibody Overview
• Humanized version of the Antibody M195 directed against CD33

• Clone
• HuM195

• Antibody Isotype
• IgG1

• Linker
• AcBut

• Linker Class/Description
• Acid-labile linkers, belonging to chemically cleavable linkers, are designed based on a pH-dependent release mechanism and remain intact during systemic circulation in the blood's neutral pH environment (pH 7.3-7.5) but to undergo hydrolysis and release drug once the ADC is internalized into mildly acidic endosomal (pH 5.0-6.5) and lysosomal (pH 4.5-5.0) compartments of the cell.

• Drug
• Calicheamicin

• Drug Class/Description
• Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

• Introduction
• CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. It binds sialic acids, therefore is a member of the SIGLEC family of lectins.

• Alternative Names
• CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3;

• Gene ID
• 945

• UniProt ID
• P20138

• ADC-057LCT
• Anti-CD33mAb-DOTA-G3FC ADC

• ADC-058LCT
• Anti-CD33mAb-DOTA-NCS ADC

• ADC-059LCT
• Anti-CD33mAb-DOTA-SH ADC

• ADC-061LCT
• Anti-CD33 (HuM195)-SPDB-DM4 ADC

• FAMAB-0045CQ
• Human Anti-CD33 Recombinant Antibody (clone huM195)

• FAMAB-0045CQ-F(E)
• Human Anti-CD33 Recombinant Antibody (clone huM195); Fab Fragment

• FAMAB-0045CQ-S(P)
• Human Anti-CD33 Recombinant Antibody (clone huM195); scFv Fragment

• FAMAB-0045CQ-mRNA
• Human Anti-CD33 Antibody (clone huM195), mRNA

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