IL2-DT immunotoxin

Name: IL2-DT immunotoxin
SKU: AGTO-L078D
Rating: 5 (1 reviews)

CAT#: AGTO-L078D

This immunotoxin was achieved by conjugating/fusing the IL-2 to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cell leukaemia cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of T cell leukaemia.

Gene Expression

Normal Tissue Figure 1 Lymph node

Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg

Normal Tissue Figure 2 Tonsil

Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg

RNA Expression Figure 3 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA

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Specifications

Host Species
Human

Species Reactivity
Human

Molecule Class
IL2-DT

Toxin Description
Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.

Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.

Related Disease
T cell leukaemia

Target

Alternative Names
CD25; IDDM10; IL 2 RA; IL 2 receptor subunit alpha; IL 2R alpha chain; IL 2R subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2 RA; IL2 Receptor alpha; IL2 receptor subunit alpha; IL2-RA; IL2R alpha chain; IL2R; IL2R subunit alpha; IL2RA; IL2RA_HUMAN; Interleukin 2 receptor alpha chain; interleukin 2 receptor subunit alpha; Interleukin 2 receptor, alpha; Interleukin-2 receptor subunit alpha; Ly 43; Ly43; OTTHUMP00000019030; OTTHUMP00000019031; OTTHUMP00000019032; p55; p55 chain; T Cell Growth Factor Receptor; TAC antigen; TCGFR; Diphtheria toxin; Diphtheria-toxin; DT; DT388; DT389; DT390; DAB389

Gene ID
3559

UniProt ID
P01589

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AGTO-L078D.pdf

MSDS

MSDS - AGTO-L078D.pdf

COA

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