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PE-A*01:01/Human SART1 (KGSGKMKTE) MHC Tetramer (CAT#: MHC-LC4378)

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human SART1 of peptide KGSGKMKTE covering 736-744 and A*01:01 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.


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Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear speckles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31188/if_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nuclear speckles & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31189/405_H7_2_selected.jpg
Normal Tissue
Figure 3 IHC staining of human stomach
Figure 3 IHC staining of human stomach
(Immunohistochemical staining of human stomach shows strong nuclear positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31189/ihc_selected.jpg
Figure 4 Placenta
Figure 4 Placenta
(Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31189/66116_A_2_7.jpg
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31189/66116_B_7_5.jpg
Figure 6 Kidney
Figure 6 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31189/66116_A_9_5.jpg
Figure 7 Testis
Figure 7 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/31189/66116_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000175467-SART1

Specifications

  • Allele
  • A*01:01
  • Class
  • Class I
  • Antigen
  • SART1
  • Antigen Species
  • Human
  • Peptide
  • KGSGKMKTE
  • Range
  • 736-744
  • Conjugate
  • PE
  • Application
  • FCM

Target

  • Antigen Introduction
  • This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • SART1; U4/U6.U5 tri-snRNP-associated protein 1; Ara1; HOMS1; Snu66; SART1259; SNRNP110

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Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3173 Hi-Affi™ Recombinant Rabbit Anti-SART1 Monoclonal Antibody (DS3173AB) WB, ICC/IF, FC IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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