PE-A*02:01/Human HA-8 (RTLDKVLEV) MHC Tetramer
CAT#: MHC-LC684
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of HA-8-derived peptide of RTLDKVLEV sequence covering 149-157 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- HA-8
- Antigen Species
- Human
- Peptide
- RTLDKVLEV
- Range
- 149-157
- Conjugate
- PE
- Application
- FCM
Target
- Antigen Introduction
- Minor histocompatibility antigen (a.k.a. MHA) are receptors on the cellular surface of donated organs that are known to give an immunological response in some organ transplants. They cause problems of rejection less frequently than those of the major histocompatibility complex (MHC). Minor histocompatibility antigens (MiHAs) are diverse, short segments of proteins and are referred to as peptides . These peptides are normally around 9-12 amino acids in length and are bound to both the major histcompatibility complex (MHC) class I and class II proteins. Peptide sequences can differ among individuals and these differences arise from SNPs in the coding region of genes, gene deletions, frameshift mutations, or insertions. About a third of the characterized MiHAs come from the Y chromosome. The proteins are composed of a single immunogenic HLA allele. Prior to becoming a short peptide sequence, the proteins expressed by these polymorphic or diverse genes need to be digested in the proteasome into shorter peptides. These endogenous or self peptides are then transported into the endoplasmic reticulum with a peptide transporter pump called TAP where they encounter and bind to the MHC class I molecule. In contrast, proteins from outside cell is internalized and then binds to MHC class II molecule. These antigens are either ubiquitously expressed in most tissue like skin and intestines or restrictively expressed in the immune cells.
- Alternative Names
- PUM3; pumilio RNA binding family member 3; PEN; HA-8; PUF6; XTP5; PUF-A; HLA-HA8; KIAA0020
- Gene ID
- 9933
- UniProt ID
- Q15397
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See other products for "PUM3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC685 | APC-A*02:01/Human HA-8 (RTLDKVLEV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1177 | PE-A*02:01/Human PUM3 (RTLDKVLEV) MHC Tetramer | FCM, IHC | |
| MHC-CN1178 | APC-A*02:01/Human PUM3 (RTLDKVLEV) MHC Tetramer | FCM, IHC | |
| MHC-CN1179 | FITC-A*02:01/Human PUM3 (RTLDKVLEV) MHC Tetramer | FCM, IHC | |
| MHC-CN1180 | A*02:01/Human PUM3 (RTLDKVLEV) MHC Tetramer | FCM, IHC |
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