Protein G-vc-MMAE ADC
CAT#: ADC-180LCT
This ADC product is composed of Protein G conjuagated via a vc linker to MMAE (Protein G-vc-MMAE). It has demonstrated a response in cancer treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specifications
- Clone
- Protein G
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
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| MOB-812-F(E) | Recombinant Anti-Protein G Antibody Fab Fragment | ELISA, FuncS | Fab |
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