A*02:01/Human BIR (RLQEERTCKV) MHC Pentamer (CAT#: MHC-YF333)

• Allele
• A*02:01

• Class
• Class I

• MHC Species
• Human

• Antigen
• BIR

• Antigen Species
• Human

• Peptide
• RLQEERTCKV

• Conjugate
• Unlabeled, Biotin, R-PE, APC

• Application
• FCM

• Antigen Introduction
• Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]

• Alternative Names
• Potassium Voltage-Gated Channel Subfamily J Member 11; Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11; Potassium Channel, Inwardly Rectifying Subfamily J Member 11; Inward Rectifier K(+) Channel Kir6.2; IKATP; Inwardly-Rectifying Potassium Channel Subfamily J Member 11; Inwardly Rectifing Potassium Channel Subfamily J Member 11; Potassium Channel Inwardly Rectifing Subfamily J Member 11; ATP-Sensitive Inward Rectifier Potassium Channel 11;

• Gene ID
• 3767

• UniProt ID
• Q14654

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