A*02:01/Human BIR (RLQEERTCKV) MHC Pentamer (CAT#: MHC-YF333)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed BIR-derived peptide of RLQEERTCKV sequence and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

(Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in a subset of cells in islets of Langerhans.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48891/ihc_selected.jpg

(Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48891/121831_A_7_4.jpg

(Pancreatic endocrine cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48891/121831_A_2_3.jpg

(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48891/121831_A_5_6.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000187486-KCNJ11
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- BIR
- Antigen Species
- Human
- Peptide
- RLQEERTCKV
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
- Alternative Names
- Potassium Voltage-Gated Channel Subfamily J Member 11; Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11; Potassium Channel, Inwardly Rectifying Subfamily J Member 11; Inward Rectifier K(+) Channel Kir6.2; IKATP; Inwardly-Rectifying Potassium Channel Subfamily J Member 11; Inwardly Rectifing Potassium Channel Subfamily J Member 11; Potassium Channel Inwardly Rectifing Subfamily J Member 11; ATP-Sensitive Inward Rectifier Potassium Channel 11;
- Gene ID
- 3767
- UniProt ID
- Q14654
Downloads
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