A*02:01/HBV Pol (KLHLYSHPI) MHC Pentamer (CAT#: MHC-YF667)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed Pol-derived peptide of KLHLYSHPI sequence covering 502-510 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
Specific Inquiry
Specifications
- Allele
- A*02:01
- Class
- Class I
- Antigen
- Pol
- Antigen Species
- HBV
- Peptide
- KLHLYSHPI
- Range
- 502-510
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated together with the P protein, and reverse-transcribed inside the nucleocapsid. Initiation of reverse-transcription occurs first by binding the epsilon loop on the pgRNA genome, and is initiated by protein priming, thereby the 5'-end of (-)DNA is covalently linked to P protein. Partial (+)DNA is synthesized from the (-)DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA). The activity of P protein does not seem to be necessary for cccDNA generation, and is presumably released from (+)DNA by host nuclear DNA repair machinery.
- Alternative Names
- Protein P; Pol; P
- Gene ID
- 944565
- UniProt ID
- Q91EI0
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1232CT | Recombinant Mouse anti-Other P Monoclonal antibody (iNQW 234) | ELISA, ICC/IF, IHC-Fr, WB |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF248 | A*24:02/HBV pol (KYTSFPWLL) MHC Monomer | MHC Multimer | |
| MHC-YF262 | A*02:01/HBV pol (FLLSLGIHL) MHC Monomer | MHC Multimer | |
| MHC-YF294 | A*02:01/HBV pol 538 (YMDDVVLGV) MHC Monomer | MHC Multimer | |
| MHC-YF666 | A*02:01/HBV Pol (GLSRYVARL) MHC Pentamer | FCM | |
| MHC-YF669 | A*02:01/HBV Polymerase (YMDDVVLGA) MHC Pentamer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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