A*02:01/Human MAGEC2 (LLFGLALIEV) MHC Pentamer (CAT#: MHC-YF542)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed MAGEC2-derived peptide of LLFGLALIEV sequence covering 191-200 and A*02:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
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MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62230/1854_H6_7_selected.jpg
(Immunofluorescent staining of human cell line K-562 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62230/1854_H6_7_selected.jpg
Figure 2 High expression in testis
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62230/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62230/ihc_selected.jpg
Figure 3 Low expression in endometrium 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62230/141490_B_5_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62230/141490_B_5_3_val_selected.jpg
Figure 4 Testis
(Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: Low Intensity: Weak Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62230/141490_A_6_6.jpg
(Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: Low Intensity: Weak Quantity: 75%-25% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62230/141490_A_6_6.jpg
Figure 5 RNA cell line category: Group enriched (K-562, U-266/84)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000046774-MAGEC2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000046774-MAGEC2
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- MAGEC2
- Antigen Species
- Human
- Peptide
- LLFGLALIEV
- Range
- 191-200
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. [provided by RefSeq, Oct 2009]
- Alternative Names
- MAGE Family Member C2; Cancer/Testis Antigen 10; Melanoma Antigen, Family E, 1, Cancer/Testis Specific; Hepatocellular Carcinoma-Associated Antigen 587; Melanoma Antigen Family C2; MAGE-C2 Antigen; MAGE-E1 Antigen;
- Gene ID
- 51438
- UniProt ID
- Q9UBF1
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF470 | A*02:01/Human HCA587 (FLAKLNNTV) MHC Pentamer | FCM | |
| MHC-YF541 | A*02:01/Human MAGEC2 (ALKDVEERV) MHC Pentamer | FCM |
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