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    A*02:01/Human MAGE-A10 (GLYDGMEHL) MHC Monomer (CAT#: MHC-YF237)

    This product is a MHC monomer of biotinylated peptide/MHC complex composed MAGE-A10-derived peptide of GLYDGMEHL sequence and A*02:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.

    Specific Inquiry
    • Size:
    Custom Production

    MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

    Peptide Sequence *:
    Allele Requested *:
    Antigen Species:
    Antigen Molecule:
    Sequence Position:
    Form Requested *:
    Conjugation *:
    Size *:
    Comments:

    Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line SH-SY5Y
    Figure 1 IF staining of human cell line SH-SY5Y
    (Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & cytosol.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/70780/1696_F2_1_selected.jpg
    Normal Tissue
    Figure 2 IHC staining of human placenta
    Figure 2 IHC staining of human placenta
    (Immunohistochemical staining of human placenta shows strong nuclear and cytoplasmic positivity in trophoblastic cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3333/ihc_selected.jpg
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3333/9906_B_7_5.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3333/9906_A_8_5.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3333/9906_A_4_6.jpg
    Figure 6 Placenta
    Figure 6 Placenta
    (Decidual cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear Trophoblastic cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/3333/9906_A_3_7.jpg
    RNA Expression
    Figure 7 RNA cell line category: Cell line enriched (GAMG)
    Figure 7 RNA cell line category: Cell line enriched (GAMG)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000124260-MAGEA10

    Specifications

    • Allele
    • A*02:01
    • Class
    • Class I
    • MHC Species
    • Human
    • Antigen
    • MAGE-A10
    • Antigen Species
    • Human
    • Peptide
    • GLYDGMEHL
    • Conjugate
    • Biotin
    • Application
    • MHC Multimer

    Target

    • Antigen Introduction
    • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.
    • Alternative Names
    • CT1.10; MAGE10

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "MAGEA10"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
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    CAT Product Name Application Type
    MHC-CN1013 PE-A*02:01/Human MAGEA10 (GLYDGMEHL) MHC Tetramer FCM, IHC
    MHC-CN1014 APC-A*02:01/Human MAGEA10 (GLYDGMEHL) MHC Tetramer FCM, IHC
    MHC-CN1015 FITC-A*02:01/Human MAGEA10 (GLYDGMEHL) MHC Tetramer FCM, IHC
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    Customer Reviews and Q&As

    Customer Review Q&As

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    Easy to Use
    The protocol provided was straightforward and easy to follow. I had no issues staining my cells and the results were consistent with my expectations.

    Reproducible Results
    I've been using this MHC Pentamer for several projects now, and the results have been reliable and reproducible every time. I highly recommend it for immuno-monitoring studies.

    Excellent Customer Support
    The customer service team was extremely helpful in answering all my questions regarding the product. They guided me through optimization steps for my specific assay.

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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