Anti-CD274 (clone CA051-00949) Recombinant Antibody Coupled Liposome (VS-1024-FY256)
CAT#: VS-1024-FY256
Anti-PD-L1 antibody conjugated liposomes hold significant potential in research for treating adrenocortical carcinoma by enhancing the immune response against cancer cells. By delivering targeted therapy directly to tumor sites, these liposomes could improve the efficacy of PD-L1 blockade while minimizing off-target effects. The conjugation of antibodies allows for a more precise targeting mechanism, which may result in reduced systemic toxicity and improved patient outcomes. Additionally, the use of liposomes as a delivery platform can facilitate the co-encapsulation of other therapeutic agents, potentially leading to synergistic effects and overcoming resistance mechanisms in adrenocortical carcinoma.
Anti-PD-L1 antibody conjugated liposomes hold significant potential in the research of metastatic fibrosarcoma by enhancing targeted delivery of therapeutic agents directly to tumor cells, thereby increasing treatment efficacy while minimizing systemic toxicity. These liposomes can promote an immune response by blocking the PD-L1 pathway, which is crucial for limiting T-cell activity against tumors, thus potentially improving patient outcomes in immunotherapy. Furthermore, the use of liposomes allows for controlled release of drugs, enabling sustained therapeutic effects and improved patient compliance in cancer treatment regimens.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg
Normal Tissue
Figure 4 Colon
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg
Normal Tissue
Figure 5 Placenta
Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274
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More Infomation
Specifications
- Potential Clinical Applications
- Adrenocortical carcinoma, Metastatic fbrosarcoma
Product Composition
- Clone
- CA051-00949
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was crafted to specifically bind to Programmed Death-Ligand 1 (PD-L1), a crucial molecule involved in immune suppression within the tumor microenvironment. Utilizing advanced recombinant technology, this antibody is designed to exhibit strong binding affinity and specificity, enabling its effective use in both research and clinical settings. By targeting PD-L1, the antibody can aid in the development of therapies that enhance anti-tumor immunity, offering new avenues for cancer treatment strategies.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- CD274
- Alternative Names
- CD274 Molecule; CD274 Antigen; B7 Homolog 1; Programmed Cell Death 1 Ligand 1; PDCD1 Ligand 1; PDCD1LG1; PDCD1L1
- Full Name
- CD274 Molecule
- Gene ID
- 29126
- UniProt ID
- Q9NZQ7
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. BTN/MOG family.
- Cellular Localization
- Cell membrane, Endosome, Membrane, Nucleus, Secreted
- Post Translation Modifications
- Ubiquitinated; STUB1 likely mediates polyubiquitination of PD-L1/CD274 triggering its degradation (PubMed:28813410).
Ubiquitinated by MARCHF8; leading to degradation (PubMed:34183449).
Glycosylation at Asn35, Asn192, Asn200, and Asn219 (NX_Q9NZQ7 [NX_Q9NZQ7-1])
Modification sites at PhosphoSitePlus (Q9NZQ7)
Glycosylation from GlyGen (Q9NZQ7) 5 sites
- Protein Refseq
- XP_047279218.1; XP_054218785.1; NP_001254635.1; NP_001300958.1; NP_054862.1
- Function
- Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11015443, PubMed:28813417, PubMed:28813410).
As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| NAB-305-sdAb | Recombinant Anti-Mouse Cd274 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
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| MOB-1814z | Mouse Anti-CD274 Recombinant Antibody (clone 7A5) | FC, IHC, FuncS | Mouse IgG2b |
| CAT | Product Name | Application | Type |
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| PABL-298 | Human Anti-CD274 Recombinant Antibody (clone CBLC-006) | WB, ELISA, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
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| PSBL-298 | Human Anti-CD274 Recombinant Antibody (clone CBLC-006); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
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| PFBL-298 | Human Anti-CD274 Recombinant Antibody (clone CBLC-006); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0190CL | Anti-Human CD274 Recombinant Antibody (PD1-AB1) | FC, ELISA, FuncS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0262CL | Mouse Anti-CD274 Recombinant Antibody (TAB-0262CL) | ELISA, WB, SPR, ADCC, CDC, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0263CL | Human Anti-CD274 Recombinant Antibody (TAB-0263CL) | ELISA, WB, SPR, FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0264CL | Human Anti-CD274 Recombinant Antibody (TAB-0264CL) | ELISA, WB, SPR, ADCC, CDC, FuncS, Inhib | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0265CL | Human Anti-CD274 Recombinant Antibody (TAB-0265CL) | ELISA, WB, SPR, ADCC, CDC, FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0266CL | Human Anti-CD274 Recombinant Antibody (TAB-0266CL) | ELISA, WB, SPR, ADCC, CDC, FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0267CL | Human Anti-CD274 Recombinant Antibody (TAB-0267CL) | ELISA, WB, SPR, ADCC, CDC, FuncS | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0992CL | Mouse Anti-CD274 Recombinant Antibody (TAB-0992CL) | Inhib, FC, SPR | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0993CL | Mouse Anti-CD274 Recombinant Antibody (TAB-0993CL) | FC, SPR | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0994CL | Mouse Anti-CD274 Recombinant Antibody (TAB-0994CL) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0995CL | Human Anti-CD274 Recombinant Antibody (TAB-0995CL) | ELISA, FC | Chimeric (Mouse/Human) IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0997CL | Anti-Human CD274 Recombinant Antibody (B60-55) | ELISA, FuncS, FC, PK | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1002CL | Mouse Anti-CD274 Recombinant Antibody (TAB-1002CL) | ELISA, FC | Mouse IgG, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1003CL | Human Anti-CD274 Recombinant Antibody (TAB-1003CL) | FC, ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1004CL | Human Anti-CD274 Recombinant Antibody (TAB-1004CL) | FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1009CL | Mouse Anti-CD274 Recombinant Antibody (TAB-1009CL) | WB, IHC | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0995CL-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0995CL-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0995CL-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0995CL-F(E)) | ELISA, FC | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2354MZ | Mouse Anti-CD274 Recombinant Antibody (clone NJI3) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-324CQ | Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6) | IHC-P, FC, Neut, ICC | Mouse IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-325CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-206) | Neut | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-326CQ | Human Anti-CD274 Recombinant Antibody (clone CBLS-207) | ELISA, Neut | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-327CQ | Mouse Anti-CD274 Recombinant Antibody (clone MIH1) | FC, FuncS, Neut, IHC, IF | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-328CQ | Rat Anti-CD274 Recombinant Antibody (VMC171) | Block, FC | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-329CQ | Rat Anti-CD274 Recombinant Antibody (clone 10F.9G2) | FC, IF, Block | Rat IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-330CQ | Rat Anti-CD274 Recombinant Antibody (clone MIH5) | FC, FuncS, Neut, IHC-Fr, WB | Rat IgG2a, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-331CQ | Mouse Anti-CD274 Recombinant Antibody (clone alphaPD-L1) | ELISA, Block | Mouse IgG1, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-332CQ | Rabbit Anti-CD274 Recombinant Antibody (clone CBL1009) | Block | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0548 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4049 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI116DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4050 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI117DS) | ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4051 | Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI118DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0193-YC | Human Anti-CD274 Recombinant Antibody (HPAB-0193-YC) | ELISA | Humanized IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0194-YC | Mouse Anti-CD274 Recombinant Antibody (HPAB-0194-YC) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0193-YC-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0193-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0194-YC-S(P) | Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0194-YC-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0195-YC-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0195-YC-S(P)) | SPR | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0196-YC-S(P) | Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0196-YC-S(P)) | FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0193-YC-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0193-YC-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0194-YC-F(E) | Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0194-YC-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0195-YC-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0195-YC-F(E)) | SPR | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0196-YC-F(E) | Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0196-YC-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0408-YC-VHH | Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0408-YC-VHH) | ELISA, FC, BL | Human VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-417CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-418CQ | Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-418CQ) | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0307-YC-VHH | Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0307-YC-VHH) | ELISA, FC, BL | Humanized VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0065-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0066-YJ-VHH | Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0066-YJ-VHH) | ELISA, Inihb | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC110 | Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC111 | Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced | ELISA, WB, SPR, ADCC, CDC, Inhib | Antibody hexamer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY375 | Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY32 | CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3) | FC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY65 | Human Anti-CD274 (clone MI4736) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC608 | Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608) | Block, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1152 | Anti-CD274 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1153 | Anti-Mouse CD274 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1154 | Anti-Human CD274 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC202 | Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv | ELISA, IHC, FC, IP, IF | Tandem scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC8 | SmartAb™ Recombinant Anti-CD274 pH-dependent Antibody (VS-0825-YC8) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC47 | SmartAb™ Recombinant Anti-CD274 pH-dependent Antibody (VS-0825-YC47) | ELISA, IHC, FC, IP, IF, Inhib | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC9 | Anti-CD274 Antibody Prodrug, Protease Activated (VS-1025-YC9) | ISZ, Cyt, FuncS |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1025-YC39 | Anti-CD274 Antibody Prodrug, Protease Activated (VS-1025-YC39) | ISZ, Cyt, FuncS |
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