Anti-CD274 Antibody-Cytokine Fusion Protein, IgG (VS0624W1)-TGFβ

Name: Anti-CD274 Antibody-Cytokine Fusion Protein, IgG (VS0624W1)-TGFβ
SKU: VS-0624-FY83
Rating: 5 (1 reviews)

CAT#: VS-0624-FY83

TGF-β1 plays a role in inducing induced Treg cells (iT_reg cells) with regulatory functions and Tₕ17 cells that secrete proinflammatory cytokines from CD4⁺ T cells. This product is a anti-CD274 Immunocytokine (IgG-TGFβ). It is a first-in-class bifunctional fusion protein consisting of the extracellular domain of human TGF-β receptor II (TGF-β "trap") fused to the C-terminus of each heavy chain of a PD-L1 IgG1 antibody inhibitor via a flexible linker.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg

Normal Tissue Figure 4 Colon

Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg

Normal Tissue Figure 5 Placenta

Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274

❮

❯

Specifications

Target
PD-L1

Molecule Class
IgG-TGFβ

Species Reactivity
Human

Clone
VS0624W1

Related Disease
Cancer

Cytokine 1
TGFβ

Cytokines 1 Description
Transforming growth factor β (TGF-β) is a multifunctional cytokine that belongs to the transforming growth factor superfamily, which includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all leukocyte lineages.

Cytokine 1 Species
Human

Applications
This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Introduction
Every year, thousands of dogs are diagnosed with cancer. Canine cancers share many of the characteristics of human cancers, including tissue location, tumor progression, and response to chemotherapy and radiation. Unfortunately, the canine lymphocyte population is not as well defined as human lymphocytes, and reagents targeting the immune checkpoint pathway have not been widely used in veterinary research. Interruption of the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway is an established and effective therapeutic strategy in human oncology and may also be effective in the treatment of canine cancers.

Alternative Names
CD274 Molecule; CD274 Antigen; B7 Homolog 1; Programmed Cell Death 1 Ligand 1; PDCD1 Ligand 1; PDCD1LG1; PDCD1L1; Bintrafusp alfa, M7824

Gene ID
29126

UniProt ID
Q9NZQ7

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for VS-0624-FY83. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-0624-FY83.pdf

MSDS

MSDS - VS-0624-FY83.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "Cd274"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
NAB-305-sdAb	Recombinant Anti-Mouse Cd274 VHH Single Domain Antibody	IHC, IP, FC, Neut, FUNC	Llama VHH

CAT	Product Name	Application	Type
MOB-1814z	Mouse Anti-CD274 Recombinant Antibody (clone 7A5)	FC, IHC, FuncS	Mouse IgG2b

CAT	Product Name	Application	Type
PABL-298	Human Anti-CD274 Recombinant Antibody (clone CBLC-006)	WB, ELISA, FuncS	Human IgG

CAT	Product Name	Application	Type
PSBL-298	Human Anti-CD274 Recombinant Antibody (clone CBLC-006); scFv Fragment	WB, ELISA, FuncS	Human scFv

CAT	Product Name	Application	Type
PFBL-298	Human Anti-CD274 Recombinant Antibody (clone CBLC-006); Fab Fragment	WB, ELISA, FuncS	Human Fab

CAT	Product Name	Application	Type
TAB-0190CL	Anti-Human CD274 Recombinant Antibody (PD1-AB1)	FC, ELISA, FuncS

CAT	Product Name	Application	Type
TAB-0262CL	Mouse Anti-CD274 Recombinant Antibody (TAB-0262CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Mouse IgG

CAT	Product Name	Application	Type
TAB-0263CL	Human Anti-CD274 Recombinant Antibody (TAB-0263CL)	ELISA, WB, SPR, FuncS	Humanized IgG

CAT	Product Name	Application	Type
TAB-0264CL	Human Anti-CD274 Recombinant Antibody (TAB-0264CL)	ELISA, WB, SPR, ADCC, CDC, FuncS, Inhib	Humanized IgG

CAT	Product Name	Application	Type
TAB-0265CL	Human Anti-CD274 Recombinant Antibody (TAB-0265CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Humanized IgG

CAT	Product Name	Application	Type
TAB-0266CL	Human Anti-CD274 Recombinant Antibody (TAB-0266CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Humanized IgG

CAT	Product Name	Application	Type
TAB-0267CL	Human Anti-CD274 Recombinant Antibody (TAB-0267CL)	ELISA, WB, SPR, ADCC, CDC, FuncS	Humanized IgG

CAT	Product Name	Application	Type
TAB-0992CL	Mouse Anti-CD274 Recombinant Antibody (TAB-0992CL)	Inhib, FC, SPR	Mouse IgG

CAT	Product Name	Application	Type
TAB-0993CL	Mouse Anti-CD274 Recombinant Antibody (TAB-0993CL)	FC, SPR	Mouse IgG

CAT	Product Name	Application	Type
TAB-0994CL	Mouse Anti-CD274 Recombinant Antibody (TAB-0994CL)	ELISA, FC	Mouse IgG

CAT	Product Name	Application	Type
TAB-0995CL	Human Anti-CD274 Recombinant Antibody (TAB-0995CL)	ELISA, FC	Chimeric (Mouse/Human) IgG1, κ

CAT	Product Name	Application	Type
TAB-0997CL	Anti-Human CD274 Recombinant Antibody (B60-55)	ELISA, FuncS, FC, PK	Human antibody

CAT	Product Name	Application	Type
TAB-1002CL	Mouse Anti-CD274 Recombinant Antibody (TAB-1002CL)	ELISA, FC	Mouse IgG, κ

CAT	Product Name	Application	Type
TAB-1003CL	Human Anti-CD274 Recombinant Antibody (TAB-1003CL)	FC, ELISA	Human IgG

CAT	Product Name	Application	Type
TAB-1004CL	Human Anti-CD274 Recombinant Antibody (TAB-1004CL)	FC	Human IgG

CAT	Product Name	Application	Type
TAB-1009CL	Mouse Anti-CD274 Recombinant Antibody (TAB-1009CL)	WB, IHC	Mouse IgG1, κ

CAT	Product Name	Application	Type
TAB-0995CL-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0995CL-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
TAB-0995CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0995CL-F(E))	ELISA, FC	Chimeric (Mouse/Human) Fab

CAT	Product Name	Application	Type
MOB-2354MZ	Mouse Anti-CD274 Recombinant Antibody (clone NJI3)	FC	Mouse IgG1

CAT	Product Name	Application	Type
NEUT-324CQ	Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6)	IHC-P, FC, Neut, ICC	Mouse IgG2b, κ

CAT	Product Name	Application	Type
NEUT-325CQ	Human Anti-CD274 Recombinant Antibody (clone CBLS-206)	Neut	Human IgG1, κ

CAT	Product Name	Application	Type
NEUT-326CQ	Human Anti-CD274 Recombinant Antibody (clone CBLS-207)	ELISA, Neut	Human IgG1, κ

CAT	Product Name	Application	Type
NEUT-327CQ	Mouse Anti-CD274 Recombinant Antibody (clone MIH1)	FC, FuncS, Neut, IHC, IF	Mouse IgG1, κ

CAT	Product Name	Application	Type
NEUT-328CQ	Rat Anti-CD274 Recombinant Antibody (VMC171)	Block, FC	Rat IgG2

CAT	Product Name	Application	Type
NEUT-329CQ	Rat Anti-CD274 Recombinant Antibody (clone 10F.9G2)	FC, IF, Block	Rat IgG2b, κ

CAT	Product Name	Application	Type
NEUT-330CQ	Rat Anti-CD274 Recombinant Antibody (clone MIH5)	FC, FuncS, Neut, IHC-Fr, WB	Rat IgG2a, λ

CAT	Product Name	Application	Type
NEUT-331CQ	Mouse Anti-CD274 Recombinant Antibody (clone alphaPD-L1)	ELISA, Block	Mouse IgG1, λ

CAT	Product Name	Application	Type
NEUT-332CQ	Rabbit Anti-CD274 Recombinant Antibody (clone CBL1009)	Block	Rabbit IgG

CAT	Product Name	Application	Type
MOR-0548	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4049	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI116DS)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4050	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI117DS)	ICC, IF, FC	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4051	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI118DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0193-YC	Human Anti-CD274 Recombinant Antibody (HPAB-0193-YC)	ELISA	Humanized IgG4, κ

CAT	Product Name	Application	Type
HPAB-0194-YC	Mouse Anti-CD274 Recombinant Antibody (HPAB-0194-YC)	ELISA	Mouse IgG

CAT	Product Name	Application	Type
HPAB-0193-YC-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0193-YC-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
HPAB-0194-YC-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0194-YC-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
HPAB-0195-YC-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0195-YC-S(P))	SPR	Humanized scFv

CAT	Product Name	Application	Type
HPAB-0196-YC-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0196-YC-S(P))	FC	Human scFv

CAT	Product Name	Application	Type
HPAB-0193-YC-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0193-YC-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application	Type
HPAB-0194-YC-F(E)	Mouse Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0194-YC-F(E))	ELISA	Mouse Fab

CAT	Product Name	Application	Type
HPAB-0195-YC-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0195-YC-F(E))	SPR	Humanized Fab

CAT	Product Name	Application	Type
HPAB-0196-YC-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0196-YC-F(E))	FC	Human Fab

CAT	Product Name	Application	Type
HPAB-N0408-YC-VHH	Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0408-YC-VHH)	ELISA, FC, BL	Human VHH

CAT	Product Name	Application	Type
AFC-TAB-417CQ	Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ)	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody

CAT	Product Name	Application	Type
AFC-TAB-418CQ	Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-418CQ)	ELISA, IHC, FC, IP, IF, BL	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-N0307-YC-VHH	Recombinant Humanized Anti-CD274 Single Domain Antibody (HPAB-N0307-YC-VHH)	ELISA, FC, BL	Humanized VHH

CAT	Product Name	Application	Type
NBD-0065-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH)	ELISA	Camelid VHH

CAT	Product Name	Application	Type
NBD-0066-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0066-YJ-VHH)	ELISA, Inihb	Camelid VHH

CAT	Product Name	Application	Type
VS-0924-YC110	Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC	Antibody hexamer

CAT	Product Name	Application	Type
VS-0924-YC111	Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC, Inhib	Antibody hexamer

CAT	Product Name	Application	Type
VS-1024-XY375	Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0225-XY32	CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0325-FY65	Human Anti-CD274 (clone MI4736) scFv-Fc Chimera	ELISA, Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC608	Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608)	Block, ELISA, FC, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY1152	Anti-CD274 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-XY1153	Anti-Mouse CD274 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-XY1154	Anti-Human CD274 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC202	Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv	ELISA, IHC, FC, IP, IF	Tandem scFv

CAT	Product Name	Application	Type
VS-0825-YC8	SmartAb™ Recombinant Anti-CD274 pH-dependent Antibody (VS-0825-YC8)	ELISA	Mouse IgG

CAT	Product Name	Application	Type
VS-0825-YC47	SmartAb™ Recombinant Anti-CD274 pH-dependent Antibody (VS-0825-YC47)	ELISA, IHC, FC, IP, IF, Inhib	Human IgG1 kappa

CAT	Product Name	Application	Type
VS-1025-YC9	Anti-CD274 Antibody Prodrug, Protease Activated (VS-1025-YC9)	ISZ, Cyt, FuncS

CAT	Product Name	Application	Type
VS-1025-YC39	Anti-CD274 Antibody Prodrug, Protease Activated (VS-1025-YC39)	ISZ, Cyt, FuncS

Specific Inquiry

Add to compare

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Anti-Human CTLA4 Recombinant Antibody (TAB-067) (CAT# TAB-067)
Application: WB, FuncS, IF, Neut, ELISA, FC, IP

Anti-Human CD4 Recombinant Antibody (Zanolimumab) (CAT# TAB-039)
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC

Anti-Human TNF Recombinant Antibody (TAB-010) (CAT# TAB-010)
Application: WB, FC, IP, ELISA, Neut, FuncS, IF

Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) (CAT# TAB-196)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Anti-Human IL23 Recombinant Antibody (Tildrakizumab) (CAT# TAB-875)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Anti-Human MUC5AC Recombinant Antibody (TAB-200) (CAT# TAB-200)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Anti-Human Frizzled receptor Recombinant Antibody (Vantictumab) (CAT# TAB-880)
Application: Inhib, Cyt

Anti-Human TWEAK receptor Recombinant Antibody (TAB-178) (CAT# TAB-178)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Anti-Human CD4 Recombinant Antibody (TAB-146) (CAT# TAB-146)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC

Anti-Human IL17A/IL17F Recombinant Antibody (TAB-H08) (CAT# TAB-H08)
Application: ELISA, FC, IP, FuncS, IF, Neut, WB

Anti-αvβ3 Integrin Recombinant Antibody (TAB-705) (CAT# TAB-705)
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC

Anti-Human GAST Recombinant Antibody (XPA067.06) (CAT# TAB-300CL)
Application:

Anti-Human SPP1 Recombinant Antibody (ASK8007) (CAT# TAB-582CL)
Application:

Human Anti-Human C5 Rcombinant Antibody (TP-092CL) (CAT# TP-092CL)
Application:

Abciximab (CAT# TP-100CL)
Application:

Rabbit Anti-Hypusine Recombinant Antibody (PABL-202) (CAT# PABL-202)
Application: WB, ELISA, FuncS

Recombinant Human Anti-RSV Antibody (AM14) (CAT# PABL-321)
Application: WB, ELISA, Neut, FuncS

Mouse Anti-BTN3A1 Recombinant Antibody (clone 103.2) (CAT# PABL-415)
Application: FuncS

Mouse Anti-Il2 Recombinant Antibody (PABL-609) (CAT# PABL-609)
Application: FC, FuncS, IHC, ELISA

Mouse Anti-α4β7 Recombinant Antibody (PABL-746) (CAT# PABL-746)
Application: FC

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.