Anti-CD274 Antibody-Cytokine Fusion Protein, IgG (VS0624W1)-TGFβ

Name: Anti-CD274 Antibody-Cytokine Fusion Protein, IgG (VS0624W1)-TGFβ
SKU: VS-0624-FY83
Rating: 5 (1 reviews)

CAT#: VS-0624-FY83

TGF-β1 plays a role in inducing induced Treg cells (iT_reg cells) with regulatory functions and Tₕ17 cells that secrete proinflammatory cytokines from CD4⁺ T cells. This product is a anti-CD274 Immunocytokine (IgG-TGFβ). It is a first-in-class bifunctional fusion protein consisting of the extracellular domain of human TGF-β receptor II (TGF-β "trap") fused to the C-terminus of each heavy chain of a PD-L1 IgG1 antibody inhibitor via a flexible linker.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1899_B9_6_cr5ba2049576272_selected.jpg

Subcellular Location and Protein Expression Figure 2 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1936_G3_3_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3528/1953_G5_3_blue_red_green.jpg

Normal Tissue Figure 4 Colon

Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_9_3.jpg

Normal Tissue Figure 5 Placenta

Cytotrophoblasts
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining:Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/76385/169546_A_1_7.jpg

RNA Expression Figure 6 RNA cell line category: Cell line enhanced (HDLM-2, HHSteC, U-251 MG)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120217-CD274

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Specifications

Target
PD-L1

Molecule Class
IgG-TGFβ

Species Reactivity
Human

Clone
VS0624W1

Related Disease
Cancer

Cytokine 1
TGFβ

Cytokines 1 Description
Transforming growth factor β (TGF-β) is a multifunctional cytokine that belongs to the transforming growth factor superfamily, which includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all leukocyte lineages.

Cytokine 1 Species
Human

Applications
This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

Introduction
Every year, thousands of dogs are diagnosed with cancer. Canine cancers share many of the characteristics of human cancers, including tissue location, tumor progression, and response to chemotherapy and radiation. Unfortunately, the canine lymphocyte population is not as well defined as human lymphocytes, and reagents targeting the immune checkpoint pathway have not been widely used in veterinary research. Interruption of the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway is an established and effective therapeutic strategy in human oncology and may also be effective in the treatment of canine cancers.

Alternative Names
CD274 Molecule; CD274 Antigen; B7 Homolog 1; Programmed Cell Death 1 Ligand 1; PDCD1 Ligand 1; PDCD1LG1; PDCD1L1; Bintrafusp alfa, M7824

Gene ID
29126

UniProt ID
Q9NZQ7

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Downloadable Resources

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Datasheet

Datasheet - VS-0624-FY83.pdf

MSDS

MSDS - VS-0624-FY83.pdf

COA

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TAB-0995CL-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (TAB-0995CL-F(E))	ELISA, FC	Chimeric (Mouse/Human) Fab

CAT	Product Name	Application	Type
TAB-0190CL-S(P)	Anti-Human CD274 Recombinant Antibody scFv Fragment (PD1-AB1)	FC, ELISA, FuncS
TAB-0997CL-S(P)	Anti-Human CD274 Recombinant Antibody scFv Fragment (B60-55)	ELISA	Human antibody
TAB-1002CL-S(P)	Mouse Anti-CD274 Recombinant Antibody (TAB-1002CL-S(P)); scFv Fragment	ELISA, FC	Mouse scFv
TAB-1003CL-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-1003CL-S(P))	FC, ELISA	Human scFv
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CAT	Product Name	Application	Type
TAB-0263CL-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0263CL-S(P))	ELISA, WB, SPR, FuncS	Humanized scFv
TAB-0264CL-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0264CL-S(P))	ELISA, WB, SPR, Inhib, FuncS	Humanized scFv
TAB-0265CL-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0265CL-S(P))	ELISA, WB, SPR, FuncS	Humanized scFv
TAB-0996CL-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0996CL-S(P))	ELISA, FC	Human scFv
TAB-418CQ	Anti-Human CD274 Recombinant Antibody (TAB-418CQ)	ELISA, IHC, FC, IP, IF, BL	IgG1, κ

CAT	Product Name	Application	Type
TAB-0992CL-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0992CL-S(P))	FC	Mouse scFv
TAB-0993CL-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0993CL-S(P))	FC	Mouse scFv
TAB-0994CL-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-0994CL-S(P))	ELISA, FC	Mouse scFv
TAB-1009CL-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (TAB-1009CL-S(P))	WB, IHC	Mouse scFv
TAB-1010CL-S(P)	Anti-Human CD274 Recombinant Antibody scFv Fragment	FC

CAT	Product Name	Application	Type
NEUT-324CQ	Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3.C6)	IHC-P, FC, Neut, ICC	Mouse IgG2b, κ
NEUT-325CQ	Human Anti-CD274 Recombinant Antibody (clone CBLS-206)	Neut	Human IgG1, κ
NEUT-326CQ	Human Anti-CD274 Recombinant Antibody (clone CBLS-207)	ELISA, Neut	Human IgG1, κ
NEUT-327CQ	Mouse Anti-CD274 Recombinant Antibody (clone MIH1)	FC, FuncS, Neut, IHC, IF	Mouse IgG1, κ
NEUT-330CQ	Rat Anti-CD274 Recombinant Antibody (clone MIH5)	FC, FuncS, Neut, IHC-Fr, WB	Rat IgG2a, λ

CAT	Product Name	Application	Type
NEUT-328CQ	Rat Anti-CD274 Recombinant Antibody (VMC171)	Block, FC	Rat IgG2
NEUT-329CQ	Rat Anti-CD274 Recombinant Antibody (clone 10F.9G2)	FC, IF, Block	Rat IgG2b, κ
NEUT-331CQ	Mouse Anti-CD274 Recombinant Antibody (clone alphaPD-L1)	ELISA, Block	Mouse IgG1, λ
NEUT-332CQ	Rabbit Anti-CD274 Recombinant Antibody (clone CBL1009)	Block	Rabbit IgG

CAT	Product Name	Application	Type
MOR-0548	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone DS548AB)	ELISA	Rabbit IgG
MOR-4049	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI116DS)	ELISA	Rabbit IgG
MOR-4050	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI117DS)	ICC, IF, FC	Rabbit IgG
MOR-4051	Hi-Affi™ Rabbit Anti-CD274 Recombinant Antibody (clone SI118DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0196-YC	Human Anti-CD274 Recombinant Antibody (HPAB-0196-YC)	FC	Human IgG
HPAB-0197-YC	Rabbit Anti-CD274 Recombinant Antibody (HPAB-0197-YC)	ELISA, FC	Rabbit IgG
HPAB-0198-YC	Mouse Anti-CD274 Recombinant Antibody (HPAB-0198-YC)	ELISA, FC, Block	Mouse IgG
HPAB-0199-YC	Human Anti-CD274 Recombinant Antibody (HPAB-0199-YC)	ELISA, FC, Block	Chimeric (mouse/human) IgG4, κ
HPAB-0200-YC	Human Anti-CD274 Recombinant Antibody (HPAB-0200-YC)	ELISA, FC, Block	Humanized IgG4, κ

CAT	Product Name	Application	Type
HPAB-0197-YC-S(P)	Rabbit Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0197-YC-S(P))	ELISA, FC	Rabbit scFv
HPAB-0198-YC-S(P)	Mouse Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0198-YC-S(P))	ELISA, FC, Block	Mouse scFv
HPAB-0199-YC-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0199-YC-S(P))	ELISA, FC, Block	Mouse scFv
HPAB-0200-YC-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0200-YC-S(P))	ELISA, FC, Block	Humanized scFv
HPAB-0201-YC-S(P)	Human Anti-CD274 Recombinant Antibody; scFv Fragment (HPAB-0201-YC-S(P))	ELISA, FC, Block, FuncS	Human scFv

CAT	Product Name	Application	Type
HPAB-N0326-YC-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-N0326-YC-F(E))	ELISA, FuncS	Human Fab
HPAB-0561LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0561LY-F(E))	ELISA, Block	Chimeric (mouse/human) Fab
HPAB-0562LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0562LY-F(E))	ELISA, Block	Chimeric (mouse/human) Fab
HPAB-0563LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0563LY-F(E))	ELISA, Block	Chimeric (mouse/human) Fab
HPAB-0564LY-F(E)	Human Anti-CD274 Recombinant Antibody; Fab Fragment (HPAB-0564LY-F(E))	ELISA, Block	Chimeric (mouse/human) Fab

CAT	Product Name	Application	Type
AFC-TAB-417CQ	Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-417CQ)	ELISA, IHC, FC, IP, IF, Inhib	ADCC enhanced antibody
AFC-TAB-418CQ	Afuco™ Anti-CD274 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-418CQ)	ELISA, IHC, FC, IP, IF, BL	ADCC enhanced antibody

CAT	Product Name	Application	Type
NBD-0065-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0065-YJ-VHH)	ELISA	Camelid VHH
NBD-0066-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0066-YJ-VHH)	ELISA, Inihb	Camelid VHH
NBD-0067-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0067-YJ-VHH)	ELISA, FC	Camelid VHH
NBD-0068-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0068-YJ-VHH)	ELISA, FC	Camelid VHH
NBD-0069-YJ-VHH	Camelid Anti-CD274 Recombinant Single Domain Antibody (NBD-0069-YJ-VHH)	ELISA, FC	Camelid VHH

CAT	Product Name	Application	Type
VS-0924-YC110	Mouse Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC110), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC	Antibody hexamer
VS-0924-YC111	Human Anti-CD274 Recombinant Antibody Hexamer (VS-0924-YC111), CDC Enhanced	ELISA, WB, SPR, ADCC, CDC, Inhib	Antibody hexamer

CAT	Product Name	Application	Type
VS-1024-XY375	Mouse Anti-NHP CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0225-XY32	CytoStream™ Mouse Anti-CD274 Recombinant Antibody (clone 29E.2A3)	FC	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0325-FY65	Human Anti-CD274 (clone MI4736) scFv-Fc Chimera	ELISA, Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC608	Recombinant Anti-CD274 Vesicular Antibody, EV Displayed (VS-0425-YC608)	Block, ELISA, FC, Cell-uptake

CAT	Product Name	Application
VS-0525-XY1152	Anti-CD274 Immunohistochemistry Kit	IHC
VS-0525-XY1153	Anti-Mouse CD274 Immunohistochemistry Kit	IHC
VS-0525-XY1154	Anti-Human CD274 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC202	Recombinant Anti-CD274 Biparatopic Antibody, Tandem scFv	ELISA, IHC, FC, IP, IF	Tandem scFv

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