Anti-CD274 Antibody-Cytokine Fusion Protein, IgG (VS0624W1)-TGFβ (CAT#: VS-0624-FY83)

• Target
• PD-L1

• Molecule Class
• IgG-TGFβ

• Species Reactivity
• Human

• Clone
• VS0624W1

• Related Disease
• Cancer

• Cytokine 1
• TGFβ

• Cytokines 1 Description
• Transforming growth factor β (TGF-β) is a multifunctional cytokine that belongs to the transforming growth factor superfamily, which includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other signaling proteins. TGFB proteins are produced by all leukocyte lineages.

• Cytokine 1 Species
• Human

• Applications
• This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• Every year, thousands of dogs are diagnosed with cancer. Canine cancers share many of the characteristics of human cancers, including tissue location, tumor progression, and response to chemotherapy and radiation. Unfortunately, the canine lymphocyte population is not as well defined as human lymphocytes, and reagents targeting the immune checkpoint pathway have not been widely used in veterinary research. Interruption of the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway is an established and effective therapeutic strategy in human oncology and may also be effective in the treatment of canine cancers.

• Alternative Names
• CD274 Molecule; CD274 Antigen; B7 Homolog 1; Programmed Cell Death 1 Ligand 1; PDCD1 Ligand 1; PDCD1LG1; PDCD1L1; Bintrafusp alfa, M7824

• Gene ID
• 29126

• UniProt ID
• Q9NZQ7

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