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    Mouse Anti-CD44 Recombinant Antibody (clone HI44a) (CAT#: HPAB-0047-YJ)

    This product is a recombinant mouse antibody that recognizes human CD44. CD44 is a cell surface antigen that expresses on leukemia blasts from most acute myeloid leukemia (AML) patients. Mab HI44a effectively induces both differentiation and apoptosis of AML cells and suggest that this activity of the anti-CD44 antibody may be associated with its inhibitory effect on c-myc transcript expression. This antibody can be used in the treatment of leukemia.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & the Golgi apparatus.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/316/203_H10_1_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/112/if_selected.jpg
    Figure 3 IHC staining of human vagina
    Figure 3 IHC staining of human vagina
    (Immunohistochemical staining of human vagina shows strong cytoplasmic positivity in squamous epithelial cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/316/5_B_2_2_selected.jpg
    Normal Tissue
    Figure 4 Colon
    Figure 4 Colon
    (Endocrine cells
    Staining: High
    Intensity: Strong
    Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Enterocytes
    Staining: Medium
    Intensity: Strong
    Quantity: <25%
    Goblet cells
    Staining: Medium
    Intensity: Strong
    Quantity: <25%
    Mucosal lymphoid cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Peripheral nerve/ganglion
    Staining: High
    Intensity: Strong
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_9_3.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli
    Staining: Medium
    Intensity: Strong
    Quantity: <25%
    Distal tubules
    Staining: Medium
    Intensity: Strong
    Quantity: <25%
    Proximal tubules (cell body)
    Staining: Medium
    Intensity: Strong
    Quantity: <25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_8_5.jpg
    Figure 6 Skin
    Figure 6 Skin
    (Cells in basal layer
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Cells in spinous layer
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Fibrohistiocytic cells
    Staining: High
    Intensity: Strong
    Langerhans cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Lymphocytes
    Staining: High
    Intensity: Strong
    Melanocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_B_7_1.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/5785/16384_A_7_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1)
    Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026508-CD44
    Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1)
    Figure 8 RNA cell line category: Cell line enhanced (hTERT-RPE1)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000026508-CD44

    Specifications

    • Host Species
    • Mouse
    • Type
    • Mouse IgG2a
    • Specificity
    • Human CD44
    • Species Reactivity
    • Human
    • Clone
    • HI44a
    • Applications
    • WB, IF, FC, FuncS
    • Related Disease
    • Leukemia

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE and HPLC analysis
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • This antibody has been tested for use in Functional Assay.

    Target

    • Alternative Names
    • CD44 Molecule (Indian Blood Group); Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein 1; Hyaluronate Receptor; Hermes Antigen; CD44 Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; HI44a

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

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    CAT Product Name Application Type
    TAB-727 Anti-CD44 Recombinant Antibody (Bivatuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1
    TAB-236LC Anti-Human CD44 Recombinant Antibody (huPTA-4621) FuncS Humanized antibody
    TAB-236LC-S(P) Anti-Human CD44 Recombinant Antibody scFv Fragment (huPTA-4621) FC Humanized antibody
    TAB-236LC-F(E) Anti-Human CD44 Recombinant Antibody Fab Fragment (huPTA-4621) FC Humanized antibody

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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