Anti-FOXM1 (clone W24V96) Recombinant Antibody Coupled Liposome (VS-1024-FY98) (CAT#: VS-1024-FY98)

• Potential Clinical Applications
• Glioma

• Clone
• W24V96

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that is designed to selectively bind to human FOXM1, a transcription factor that plays a critical role in cell proliferation, differentiation, and tumor progression.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• FOXM1

• Introduction
• The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.

• Alternative Names
• Forkhead Box M1; M-Phase Phosphoprotein 2; Hepatocyte Nuclear Factor 3 Forkhead Homolog 11; Winged-Helix Factor From INS-1 Cells; Forkhead-Related Protein FKHL16; MPM-2 Reactive Phosphoprotein 2; Transcription Factor Trident; HNF-3/Fork-Head Homolog 11; FKHL16; HFH-11; HFH11; MPP2

• Full Name
• Forkhead Box M1

• Gene ID
• 2305

• UniProt ID
• Q08050

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Phosphorylated in M (mitotic) phase (PubMed:17101782, 19160488, 30139873).
  Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair (PubMed:17101782).
  Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1.

• Protein Refseq
• XP_011519234.1; XP_047284503.1; XP_047284505.1; XP_047284506.1; XP_054227453.1

• Function
• Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, 20360045).
  Plays a role in the control of cell proliferation.

Select a product category from the dropdown menu below to view related products.