Anti-FOXM1 (clone W24V96) Recombinant Antibody Coupled Liposome (VS-1024-FY98)
CAT#: VS-1024-FY98
Anti-FOXM1 antibody-conjugated liposomes may enhance drug targeting and therapeutic efficacy in gliomas by targeting the FOXM1 protein. The overexpression of FOXM1 in glioma cells is associated with tumor invasiveness and drug resistance, making it a significant therapeutic target. This liposomal system could effectively deliver anticancer drugs, increase intracellular drug concentrations, and reduce side effects on normal cells. Ultimately, the use of anti-FOXM1 antibody-conjugated liposomes may improve treatment prognosis and survival rates for glioma patients.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nucleoli & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17832/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17832/40227_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17832/40227_A_8_3.jpg
Normal Tissue
Figure 4 Pancreas
Exocrine glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17832/40227_A_1_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17832/40227_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17832/40227_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/17832/40227_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111206-FOXM1
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V96
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that is designed to selectively bind to human FOXM1, a transcription factor that plays a critical role in cell proliferation, differentiation, and tumor progression.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- FOXM1
- Introduction
- The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- Forkhead Box M1; M-Phase Phosphoprotein 2; Hepatocyte Nuclear Factor 3 Forkhead Homolog 11; Winged-Helix Factor From INS-1 Cells; Forkhead-Related Protein FKHL16; MPM-2 Reactive Phosphoprotein 2; Transcription Factor Trident; HNF-3/Fork-Head Homolog 11; FKHL16; HFH-11; HFH11; MPP2
- Full Name
- Forkhead Box M1
- Gene ID
- 2305
- UniProt ID
- Q08050
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated in M (mitotic) phase (PubMed:17101782, 19160488, 30139873).
Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair (PubMed:17101782).
Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1.
- Protein Refseq
- XP_011519234.1; XP_047284503.1; XP_047284505.1; XP_047284506.1; XP_054227453.1
- Function
- Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, 20360045).
Plays a role in the control of cell proliferation.
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3417z | Mouse Anti-FOXM1 Recombinant Antibody (clone 20A10) | WB, ELISA, ICC, IF | Mouse IgG2a, κ |
| MOB-1066MZ | Recombinant Mouse Anti-Human FOXM1 Antibody (clone 0.U.277), FITC-Conjugated | ICC | Mouse antibody |
| MRO-1870-CN | Rabbit Anti-FOXM1 Polyclonal Antibody (MRO-1870-CN) | WB, IF, FC | Rabbit IgG |
| VS3-XY724 | Mouse Anti-FOXM1 Recombinant Antibody (clone 4G1) | WB, IP, IF | Mouse IgG1 |
| VS7-HM965 | Mouse Anti-FOXM1 Recombinant Antibody (clone 6F11A8) | FCM | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0689 | PE-A*24:02/Human FOXM1 (IYTWIEDHF) MHC Tetramer | FCM, IHC | |
| MHC-CN0690 | APC-A*24:02/Human FOXM1 (IYTWIEDHF) MHC Tetramer | FCM, IHC | |
| MHC-CN0691 | FITC-A*24:02/Human FOXM1 (IYTWIEDHF) MHC Tetramer | FCM, IHC | |
| MHC-CN0692 | A*24:02/Human FOXM1 (IYTWIEDHF) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2629 | Anti-FOXM1 Immunohistochemistry Kit | IHC |
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