Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Dalotuzumab), ADCC Enhanced (CAT#: AFC-TAB-736)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to IGF1R. Dalotuzumab is a humanized monoclonal antibody designed for the treatment of cancers.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg
Figure 2 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg
Figure 3 Liver
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg
Figure 4 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg
Figure 6 Heart muscle
(Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg
(Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg
Figure 7 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized (from mouse)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Dalotuzumab
- Applications
- FC, IP, ELISA, Neut, FuncS, IF
- Conjugate
- Unconjugated
- Generic Name
- Dalotuzumab
- Related Disease
- Solid tumors
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Dalotuzumab; 1005389-60-5; MK-0646; MK0646; h7C10; IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; MGC142170; MGC142172;
- Gene ID
- 3480
- UniProt ID
- P08069
Related Resources
Please refer to Dalotuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Dalotuzumab.
Insulin Signaling Pathway
Endocrine Resistance
Type I Diabetes Mellitus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "dalotuzumab"
Anti-IGF1R Recombinant Antibody (Dalotuzumab)Recombinant humanized (from mouse) antibody expressed in CHO binding to IGF1R. Dalotuzumab is a humanized monoclonal antibody designed for the treatment of cancers.
See other products for "Clone DalotuzumAb"
See other products for "IGF1R"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-091 | Recombinant Anti-human IGF1R VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-096ZJ | Anti-Human IGF-1R Therapeutic Single Domain Antibody (IGF1 R-3) | ELISA, IHC, IF, WB | Single domain antibody |
| HPAB-1545-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (m632) | WB, ELISA | Llama VHH |
| HPAB-1546-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (m636) | WB, ELISA | Llama VHH |
| HPAB-1547-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (m546) | WB, ELISA | Llama VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-199 | Human Anti-IGF1R Recombinant Antibody (TAB-199) | FC, IP, ELISA, Neut, FuncS, IF, ICC | Human IgG1, κ |
| TAB-078 | Anti-Human IGF1 Receptor Recombinant Antibody (Cixutumumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - lambda |
| TAB-209 | Anti-Human IGF1 Receptor Recombinant Antibody (Robatumumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - kappa |
| TAB-052ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (18) | ELISA, FC, IF, IP | Human antibody |
| TAB-053ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (IR3) | ELISA, FC, WB | Human antibody |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L024E | IGF1-PE immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L024D | IGF1-DT immunotoxin | Cytotoxicity assay, Functional assay |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-371CL | Afuco™ Anti-Human IGF1R Antibody, ADCC Enhanced (AFC-371CL) | ELISA | ADCC enhanced antibody |
| AFC-TAB-199 | Afuco™ Anti-IGF1R Recombinant Antibody (AFC-TAB-199), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | Human IgG1, κ |
| AFC-TAB-209 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Robatumumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-078 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Cixutumumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-232 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Figitumumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-591 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-14); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| PFBL-592 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-7); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| HPAB-0084-YC-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0084-YC-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0085-YC-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0085-YC-F(E)) | Block, FuncS, FC, ELISA | Human Fab |
| HPAB-0210CQ-F(E) | Human Anti-IGF1R Recombinant Antibody (clone 15H12); Fab Fragment | ELISA, FC, Neut | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-009ZJ-F(E)) | ELISA, FC | Mouse Fab |
| TAB-010ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11) | ELISA, Neut, FC, IHC | |
| TAB-011ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-011ZJ-F(E)) | ELISA, FC, WB, Inhib | Mouse Fab |
| TAB-012ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-012ZJ-F(E)) | ELISA, FC, WB, Inhib | Mouse Fab |
| TAB-014ZJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-014ZJ-F(E)) | ELISA, FC, Inhib, IP | Mouse Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-035ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-035ZJ-F(E)) | ELISA, FC | Humanized Fab |
| TAB-036ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (H0L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
| TAB-037ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (H1L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
| TAB-038ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-038ZJ-F(E)) | ELISA, FC, Inhib, IP | Humanized Fab |
| TAB-051ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-051ZJ-F(E)) | ELISA, IHC, IF, WB | Humanized Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-084ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-084ZJ-F(E)) | ELISA, FC | Chimeric (mouse/human) Fab |
| TAB-085ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (6E11c) | ELISA, Neut, FC, IHC | Chimeric antibody (mouse/human) |
| TAB-086ZJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (TAB-086ZJ-F(E)) | ELISA, FC, Inhib, IP | Chimeric (mouse/human) Fab |
| TAB-087ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch7C2) | ELISA | Chimeric antibody (mouse/human) |
| TAB-093ZJ-F(E) | Anti-Human IGF-1R Recombinant Antibody Fab Fragment (ch9E11) | ELISA | Chimeric antibody (mouse/human) |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0103MZ | Chicken Anti-CD221 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1075CQ | Mouse Anti-IGF1R Recombinant Antibody (clone alphaIR3) | FC, IP, Neut, ICC, IF | Mouse IgG1 |
| NEUT-1076CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 33255.111) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1081CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL453) | WB, ELISA, Neut | Mouse IgG1 |
| NEUT-1082CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL080) | Neut, WB | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1077CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 1H7) | FC, Block, IHC, IP, WB | Mouse IgG1, κ |
| NEUT-1078CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-60) | Inhib, ICC, IF, IP, WB | Mouse IgG2a, κ |
| NEUT-1079CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 17-69) | Inhib, IP | Mouse IgG1 |
| NEUT-1080CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-57) | Inhib, IP | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1755 | Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB) | IP, ELISA | Rabbit IgG |
| MOR-4684 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH198DS) | WB, ELISA | Rabbit IgG |
| MOR-4685 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH199DS) | WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-055CQ | Mouse Anti-IGF1R Recombinant Antibody (clone YC119) | WB, IP, IHC-P | Mouse IgG2a |
| TAB-478CQ | Human Anti-IGF1R Recombinant Antibody (clone DalotuzumAb) | ELISA, IHC, FC, IP, IF, WB | Humanized IgG1, κ |
| HPAB-0210CQ | Human Anti-IGF1R Recombinant Antibody (clone 15H12) | ELISA, FC, Neut | Human IgG3, κ |
| HPAB-0211CQ | Human Anti-IGF1R Recombinant Antibody (clone 1H3) | ELISA, FC, Neut | Human IgG |
| HPAB-0212CQ | Human Anti-IGF1R Recombinant Antibody (clone 11A4) | ELISA, FC, Block | Human IgG1 |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-041CN | Mouse Anti-IGF1R Recombinant Antibody (NS-041CN) | ELISA, WB, FC | Mouse IgG |
| NS-041CN-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (NS-041CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| NS-041CN-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P)) | ELISA, WB, FC | Mouse scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1548-FY-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-1548-FY-F(E)) | ELISA | Human Fab |
| HPAB-0456-YJ-S(P) | Human Anti-IGF1R Recombinant Antibody (clone DB#2); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
| HPAB-0457-YJ-S(P) | Human Anti-IGF1R Recombinant Antibody (clone DB#7); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
| HPAB-1945-FY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-1945-FY-S(P)) | Inhib | Human scFv |
| HPAB-2063-FY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-2063-FY-S(P)) | IA | Human scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AFC-TAB-736. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.