Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Robatumumab), ADCC Enhanced (CAT#: AFC-TAB-209)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IGF1 Receptor. Robatumumab (proposed INN) is a monoclonal antibody and an antineoplastic by Schering-Plough. It binds to CD221, the insulin-like growth factor 1 receptor.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg
Figure 2 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg
Figure 3 Liver
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg
(Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg
Figure 4 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg
(Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg
(Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg
Figure 6 Heart muscle
(Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg
(Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg
Figure 7 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Robatumumab
- Applications
- FuncS, IF, Neut, ELISA, FC, IP
- Conjugate
- Unconjugated
- Generic Name
- Robatumumab
- Related Disease
- Blood cancers
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Robatumumab; 934235-44-6; SCH 717454; 19D12; IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor; MGC142170; MGC142172;
- Gene ID
- 3480
- UniProt ID
- P08069
Related Resources
Please refer to Robatumumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Robatumumab.
Insulin Signaling Pathway
Endocrine Resistance
Type I Diabetes Mellitus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Robatumumab"
Anti-Human IGF1 Receptor Recombinant Antibody (Robatumumab)Recombinant monoclonal antibody to IGF1 Receptor. Robatumumab (proposed INN) is a monoclonal antibody and an antineoplastic by Schering-Plough. It binds to CD221, the insulin-like growth factor 1 receptor.
See other products for "IGF1R"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1121z | Mouse Anti-IGF1R Recombinant Antibody (clone 19H8) | WB, ELISA, IHC | Mouse IgG2b |
| PABL-596 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-14) | WB, ELISA, FuncS | Mouse IgG |
| PABL-597 | Mouse Anti-IGF1R Recombinant Antibody (clone mAb 83-7) | WB, ELISA, FuncS | Mouse IgG |
| MOB-055CQ | Mouse Anti-IGF1R Recombinant Antibody (clone YC119) | WB, IP, IHC-P | Mouse IgG2a |
| TAB-478CQ | Human Anti-IGF1R Recombinant Antibody (clone DalotuzumAb) | ELISA, IHC, FC, IP, IF, WB | Humanized IgG1, κ |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-091 | Recombinant Anti-human IGF1R VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-096ZJ | Anti-Human IGF-1R Therapeutic Single Domain Antibody (TAB-096ZJ) | ELISA, IHC, IF, WB | Single domain antibody |
| HPAB-1545-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1545-FY) | WB, ELISA | Llama VHH |
| HPAB-1546-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1546-FY) | WB, ELISA | Llama VHH |
| HPAB-1547-FY | Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1547-FY) | WB, ELISA | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-736 | Anti-IGF1R Recombinant Antibody (Dalotuzumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
| TAB-035ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-035ZJ) | ELISA, FC | Humanized IgG |
| TAB-036ZJ | Anti-Human IGF-1R Recombinant Antibody (H0L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
| TAB-037ZJ | Anti-Human IGF-1R Recombinant Antibody (H1L0 IgGIm(AA)) | ELISA, Neut, FC, IHC | Humanized antibody |
| TAB-038ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-038ZJ) | FuncS, IP, Inhib, IF | Humanized IgG1 |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L024E | IGF1-PE immunotoxin | Cytotoxicity assay, Functional assay | |
| AGTO-L024D | IGF1-DT immunotoxin | Cytotoxicity assay, Functional assay |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-371CL | Afuco™ Anti-Human IGF1R Antibody, ADCC Enhanced (AFC-371CL) | ELISA | ADCC enhanced antibody |
| AFC-TAB-199 | Afuco™ Anti-IGF1R Recombinant Antibody (AFC-TAB-199), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | Human IgG1, κ |
| AFC-TAB-736 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Dalotuzumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-078 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Cixutumumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-232 | Afuco™ Anti-IGF1R ADCC Recombinant Antibody (Figitumumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009ZJ | Mouse Anti-IGF1R Recombinant Antibody (TAB-009ZJ) | ELISA, FC | Mouse IgG1, κ |
| TAB-010ZJ | Anti-Human IGF-1R Recombinant Antibody (6E11) | ELISA, Neut, FC, IHC | |
| TAB-011ZJ | Mouse Anti-IGF1R Recombinant Antibody (TAB-011ZJ) | ELISA, FC, WB, Inhib | Mouse IgG2, κ |
| TAB-012ZJ | Mouse Anti-IGF1R Recombinant Antibody (TAB-012ZJ) | ELISA, FC, WB, Inhib | Mouse IgG2, κ |
| TAB-013ZJ | Anti-Human IGF-1R Recombinant Antibody (1H7) | WB, Inhib |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-052ZJ | Anti-Human IGF-1R Recombinant Antibody (18) | IHC, ELISA, FC, IF, IP | Human antibody |
| TAB-053ZJ | Anti-Human IGF-1R Recombinant Antibody (IR3) | ELISA, FC, WB | Human antibody |
| TAB-054ZJ | Anti-Human IGF-1R Recombinant Antibody (IR10) | ELISA, FC, WB | Human antibody |
| TAB-055ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-055ZJ) | ELISA | Human IgG |
| TAB-056ZJ | Human Anti-IGF1R Recombinant Antibody (TAB-056ZJ) | FC, WB | Human IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-084ZJ-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-084ZJ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-085ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (6E11c) | ELISA, Neut, FC, IHC | Chimeric antibody (mouse/human) |
| TAB-086ZJ-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (TAB-086ZJ-S(P)) | ELISA, FC, Inhib, IP | Mouse scFv |
| TAB-087ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (ch7C2) | ELISA | Chimeric antibody (mouse/human) |
| TAB-093ZJ-S(P) | Anti-Human IGF-1R Recombinant Antibody scFv Fragment (ch9E11) | ELISA | Chimeric antibody (mouse/human) |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0103MZ | Chicken Anti-CD221 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1075CQ | Mouse Anti-IGF1R Recombinant Antibody (clone alphaIR3) | FC, IP, Neut, ICC, IF | Mouse IgG1 |
| NEUT-1076CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 33255.111) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1081CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL453) | WB, ELISA, Neut | Mouse IgG1 |
| NEUT-1082CQ | Mouse Anti-IGF1R Recombinant Antibody (clone CBL080) | Neut, WB | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1077CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 1H7) | FC, Block, IHC, IP, WB | Mouse IgG1, κ |
| NEUT-1078CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-60) | Inhib, ICC, IF, IP, WB | Mouse IgG2a, κ |
| NEUT-1079CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 17-69) | Inhib, IP | Mouse IgG1 |
| NEUT-1080CQ | Mouse Anti-IGF1R Recombinant Antibody (clone 24-57) | Inhib, IP | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1755 | Rabbit Anti-IGF1R Recombinant Antibody (clone DS1755AB) | IP, ELISA | Rabbit IgG |
| MOR-4684 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH198DS) | WB, ELISA | Rabbit IgG |
| MOR-4685 | Rabbit Anti-IGF1R Recombinant Antibody (clone TH199DS) | WB | Rabbit IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-041CN | Mouse Anti-IGF1R Recombinant Antibody (NS-041CN) | ELISA, WB, FC | Mouse IgG |
| NS-041CN-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (NS-041CN-F(E)) | ELISA, WB, FC | Mouse Fab |
| NS-041CN-S(P) | Mouse Anti-IGF1R Recombinant Antibody; scFv Fragment (NS-041CN-S(P)) | ELISA, WB, FC | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0284-YJ-F(E) | Mouse Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0284-YJ-F(E)) | ELISA, FC, Inhib, FuncS | Mouse Fab |
| HPAB-0285-YJ-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-0285-YJ-F(E)) | ELISA, FC, Inhib, FuncS | Human Fab |
| HPAB-1204-FY-S(P) | Mouse Anti-IGF1R Recombinant Antibody (clone 2C6); Fab Fragment | Inhib, ELISA | Mouse Fab |
| HPAB-1205-FY-S(P) | Mouse Anti-IGF1R Recombinant Antibody (clone 9H2); Fab Fragment | Inhib, ELISA | Mouse Fab |
| HPAB-1206-FY-S(P) | Mouse Anti-IGF1R Recombinant Antibody (clone 6E11); Fab Fragment | ELISA | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1548-FY-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-1548-FY-F(E)) | ELISA | Human Fab |
| HPAB-0456-YJ-S(P) | Human Anti-IGF1R Recombinant Antibody (clone DB#2); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
| HPAB-1732-FY-F(E) | Human Anti-IGF1R Recombinant Antibody; Fab Fragment (HPAB-1732-FY-F(E)) | WB, ELISA | Human Fab |
| HPAB-1945-FY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-1945-FY-S(P)) | Inhib | Human scFv |
| HPAB-2063-FY-S(P) | Human Anti-IGF1R Recombinant Antibody; scFv Fragment (HPAB-2063-FY-S(P)) | IA | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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