Afuco™ Anti-IL2RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-004)
CAT#: AFC-TAB-004
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human CD25. It is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a chimeric CD25 monoclonal antibody of the IgG1 isotype. It acts as an antagonist at the interleukin-2(IL-2) binding site of the p55 subunit (Tac antigen) of the high affinity IL-2 receptor (CD25) on the surface of the activated T lymphocytes.
Gene Expression
Normal Tissue
Figure 1 Lymph node
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_8_8.jpg
Normal Tissue
Figure 2 Tonsil
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/54622/137874_A_4_8.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enriched (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134460-IL2RA
❮
❯
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Chimeric
- Derivation
- Chimeric (mouse/human)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- IF, IP, Neut, FuncS, ELISA, FC
- Conjugate
- Unconjugated
- Trade name
- Simulect
- Generic Name
- Basiliximab
- Related Disease
- Kidney transplant rejection, acute
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Basiliximab"
Anti-Human CD25 Recombinant Antibody (Basiliximab)Recombinant monoclonal antibody to Human CD25. Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells. It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a chimeric CD25 monoclonal antibody of the IgG1 isotype. It acts as an antagonist at the interleukin-2(IL-2) binding site of the p55 subunit (Tac antigen) of the high affinity IL-2 receptor (CD25) on the surface of the activated T lymphocytes.
DrugMonitor™ Anti-Basiliximab Antibody (VS-1224-YC163)Basiliximab is a recombinant chimeric (murine/human) monoclonal antibody functioning as an immunosuppressant by binding to and blocking the IL-2R alpha on activated T-lymphocytes. The DrugMonitor™ Anti-Basiliximab Antibody (VS-1224-YC163) is an anti-drug antibody (ADA) against Basiliximab. This drug-based antibody is raised in mice immunized with the Basiliximab. The anti-Basiliximab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Basiliximab in samples.
See other products for "IL2RA"
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| CAT | Product Name | Application | Type |
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| PABX-030 | Recombinant Human Anti-CD25 Antibody (SDZCHII621) | Neut, FuncS | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-641LC | Anti-human IL2RA Recombinant Antibody (TAB-641LC) | ELISA | |
| TAB-641LC-S(P) | Anti-human IL2RA scFv Fragment (TAB-641LC-S(P)) | ELISA | |
| TAB-641LC-F(E) | Anti-human IL2RA Fab Fragment (TAB-641LC-F(E)) | ELISA | |
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| CAT | Product Name | Application | Type |
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| AGTO-L027D | anti-IL2RA immunotoxin RFT5 (scFv)-DT | Cytotoxicity assay, Functional assay | |
| AGTO-L027R | anti-IL2RA immunotoxin RFT5 (scFv)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L028E | anti-IL2RA immunotoxin RFT5 (IgG)-PE | Cytotoxicity assay, Functional assay | |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| PABX-029-F (E) | Recombinant Human Anti-CD25 Antibody Fab Fragment (Daclizumab) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-648LC | Anti-human IL2RA Recombinant Antibody (48V54S) (TAB-648LC) | FuncS | Humanized antibody |
| TAB-649LC | Anti-human IL2RA Recombinant Antibody (Dmab) (TAB-649LC) | FC | Humanized antibody |
| TAB-650LC | Human Anti-IL2RA Recombinant Antibody (TAB-650LC) | Block | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| NEUT-1348CQ | Mouse Anti-IL2RA Recombinant Antibody (clone CBL726) | WB, IHC, ICC, Neut | Mouse IgG1 |
| NEUT-1349CQ | Mouse Anti-IL2RA Recombinant Antibody (NEUT-1349CQ) | IHC, Neut, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1350CQ | Mouse Anti-IL2RA Recombinant Antibody (NEUT-1350CQ) | Block, FC, ICC, IF, IHC, IP, WB | Mouse IgG1 |
| NEUT-1356CQ | Rat Anti-Il2ra Recombinant Antibody (VMC199) | FC, IP, IHC, Block, Depletion | Rat IgG1, λ |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| FAMAB-0200CQ-S(P) | Human Anti-IL2RA Recombinant Antibody (clone huD1); scFv Fragment | ELISA, FC, Block | Humanized scFv |
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| HPAB-0559-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0559-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0560-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0560-WJ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0561-WJ-F(E) | Human Anti-IL2RA Recombinant Antibody; Fab Fragment (HPAB-0561-WJ-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| VS-0425-FY42 | Mouse Anti-IL2RA (clone mAb1) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY135 | CytoStream™ Mouse Anti-IL2RA Recombinant Antibody (clone BC96) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC386 | Recombinant Anti-IL2RA Vesicular Antibody, EV Displayed (VS-0425-YC386) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3520 | Anti-IL2RA Immunohistochemistry Kit | IHC | |
| VS-0525-XY3521 | Anti-Mouse IL2RA Immunohistochemistry Kit | IHC | |
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