Human Anti-LASV GPC Vaccinal Antibody (VS-0625-XY57)
CAT#: VS-0625-XY57
This vaccinal antibody targets LASV GPC and is suitable for ELISA, BLI, and neutralization (Neut) assays. Engineered with Fc segment modifications, it induces vaccine-like effects and enhances antiviral efficacy by optimizing Fc-mediated functions, making it a versatile tool for research on LASV immunity and therapeutic development.
Specifications
- Target
- LASV GPC
- Host Animal
- Human
- Applications
- ELISA; BLI; Neut
- Specificity
- LASV GPC
- Species Reactivity
- LASV
- Type
- Human IgG
- Purity
- >95%, determined by SDS-PAGE
- Purification
- Protein A purified
- Format
- Liquid
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
Target
- Introduction
- The Old World arenavirus Lassa virus (LASV) is the etiologic agent of the often fatal Lassa hemorrhagic fever (LF). LASV is endemic to West Africa and exhibits a case fatality rate of greater than 50% in hospitalized patients and up to 90% in the third trimester of pregnancy. LASV is an enveloped, negative-stranded RNA virus with an ambisense, bisegmented genome that encodes the following four proteins: the matrix protein (Z), viral polymerase (L), nucleoprotein (NP), and glycoprotein precursor (GPC). GPC is trafficked from the endoplasmic reticulum (ER) through the compartment, where it is heavily N-glycosylated and undergoes processing by the cellular proteases SPase and SKI-1/S1P to produce the mature, prefusion glycoprotein (GP). Each GP monomer consists of the following three noncovalently associated subunits: the stable signal peptide (SSP), the receptor binding subunit (GP1), and the fusion machinery (GP2) (14, 15). Three GP monomers associate on the viral surface to form a trimer that drives viral attachment and cell entry.
- Related Disease
- Lassa hemorrhagic fever
- Alternative Names
- Lassa virus glycoprotein precursor
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "LASV GPC"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0923-XY18 | Recombinant Human Anti-LASV GPC Antibody (clone 18.5C-M30) | ELISA, BLI, Neut | Human IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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