Anti-PD-L1 Antibody-Cytokine Fusion Protein, IgG (B50-6)-TNFSF11 (CAT#: ACFP-CQ5057)

• Target
• PD-L1

• Molecule Class
• IgG-TNFSF11

• Species Reactivity
• Human

• Expression Host
• CHO

• Clone
• B50-6

• Cytokine 1
• TNFSF11

• Cytokines 1 Description
• This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

• Cytokine 1 Species
• Human

• Applications
• This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.

• Alternative Names
• CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1

• Gene ID
• 29126

• UniProt ID
• Q9NZQ7

• TAB-0999CL
• Anti-Human CD274 Recombinant Antibody (B50-6)

• TAB-0999CL-S(P)
• Anti-Human CD274 Recombinant Antibody scFv Fragment (B50-6)

• TAB-0999CL-F(E)
• Anti-Human CD274 Recombinant Antibody Fab Fragment (B50-6)

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