Anti-PD-L1 Antibody-Cytokine Fusion Protein, IgG (B50-6)-TNFSF13B (CAT#: ACFP-CQ5141)

• Target
• PD-L1

• Molecule Class
• IgG-TNFSF13B

• Species Reactivity
• Human

• Expression Host
• CHO

• Clone
• B50-6

• Cytokine 1
• TNFSF13B

• Cytokines 1 Description
• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

• Cytokine 1 Species
• Human

• Applications
• This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.

• Alternative Names
• CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1

• Gene ID
• 29126

• UniProt ID
• Q9NZQ7

• TAB-0999CL
• Anti-Human CD274 Recombinant Antibody (B50-6)

• TAB-0999CL-S(P)
• Anti-Human CD274 Recombinant Antibody scFv Fragment (B50-6)

• TAB-0999CL-F(E)
• Anti-Human CD274 Recombinant Antibody Fab Fragment (B50-6)

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