Anti-PD-L1 Antibody-Cytokine Fusion Protein, IgG (BII61-62)-TNFSF10 (CAT#: ACFP-CQ5016)

• Target
• PD-L1

• Molecule Class
• IgG-TNFSF10

• Species Reactivity
• Human

• Expression Host
• CHO

• Clone
• BII61-62

• Cytokine 1
• TNFSF10

• Cytokines 1 Description
• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Cytokine 1 Species
• Human

• Applications
• This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

• Introduction
• This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation.

• Alternative Names
• CD274; PD-L1; PDCD1L1; B7-H; Programmed Death Ligand 1; Programmed Cell Death 1 Ligand 1; PDCD1LG1; B7H1

• Gene ID
• 29126

• UniProt ID
• Q9NZQ7

• TAB-0998CL
• Anti-Human CD274 Recombinant Antibody (BII61-62)

• TAB-0998CL-S(P)
• Anti-Human CD274 Recombinant Antibody scFv Fragment (BII61-62)

• TAB-0998CL-F(E)
• Anti-Human CD274 Recombinant Antibody Fab Fragment (BII61-62)

• ACFP-CQ1362
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• ACFP-CQ1404
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• ACFP-CQ0564
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• ACFP-CQ1026
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• ACFP-CQ0060
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