Anti-TPSAB1 (clone W24V152) Recombinant Antibody Coupled Liposome (VS-1024-FY152)
CAT#: VS-1024-FY152
Lipid nanoparticles linked with anti-TPSAB1 antibodies represent a groundbreaking strategy in combating colorectal cancer by specifically targeting the TPSAB1 protein, which is implicated in tumor progression. This novel approach not only facilitates enhanced recognition of cancer cells by the immune system but also promotes their rapid clearance, potentially leading to improved patient outcomes. By harnessing the power of targeted therapy, this innovative combination significantly increases the overall efficacy of colorectal cancer treatments, offering new hope for those affected by this disease.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows distinct cytoplasmic positivity in subsets of cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16369/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in subset of lymphoid cells outside reaction centra.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22175/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22175/52139_A_9_3.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22175/52139_A_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (HMC-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172236-TPSAB1
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More Infomation
Specifications
- Potential Clinical Applications
- Colorectal cancer
Product Composition
- Clone
- W24V152
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was specifically engineered to recognize and bind to the protein TPSAB1. TPSAB1, also known as tryptase beta-1, is a serine protease primarily found in mast cells and plays a significant role in various physiological and pathological processes, including inflammation and allergic responses.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TPSAB1
- Introduction
- Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
- Alternative Names
- Tryptase Alpha/Beta 1; Tryptase Alpha II; Tryptase Alpha-1; Tryptase Beta I; Tryptase-III; EC 3.4.21.59; Tryptase-I; Tryptase-1; TPSB1; TPS1
- Full Name
- Tryptase Alpha/Beta 1
- Gene ID
- 7177
- UniProt ID
- Q15661
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn132 and Asn233 ( NX_Q15661 [NX_Q15661-1] )
Modification sites at PhosphoSitePlus ( Q15661 )
Glycosylation from GlyConnect TRYB1_HUMAN (1861)
Glycosylation from GlyGen (Q15661) 2 sites, 11 N-linked glycans (2 sites)
- Protein Refseq
- NP_003285.2
- Function
- Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
May play a role in innate immunity.
Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates.
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Datasheet
MSDS
COA
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See other products for "TPSAB1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3662 | Rabbit Anti-TPSAB1 Recombinant Antibody (clone DS3662AB) | IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK991 | Mouse Anti-TPSAB1 Recombinant Antibody (VS3-WK991) | IHC | Mouse IgG1 |
| VS3-WK992 | Mouse Anti-TPSAB1 Recombinant Antibody (clone ABT-MCT) | IHC-P | Mouse IgG1, κ |
| VS3-WK993 | Mouse Anti-TPSAB1 Recombinant Antibody (clone PT2024) | IHC-P | Mouse IgG1, κ |
| VS3-WK994 | Rabbit Anti-TPSAB1 Recombinant Antibody (VS3-WK994) | WB, IHC, IP | Rabbit IgG |
| VS3-FY1479 | Recombinant Mouse Anti-TPSAB1 Antibody (clone 6B6B12) | ELISA, IHC, FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2340 | Anti-TPSAB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7476 | Anti-Mouse TPSAB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7475 | Anti-Human TPSAB1 Immunohistochemistry Kit | IHC |
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