Anti-TPSAB1 (clone W24V152) Recombinant Antibody Coupled Liposome (VS-1024-FY152) (CAT#: VS-1024-FY152)

• Potential Clinical Applications
• Colorectal cancer

• Clone
• W24V152

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that was specifically engineered to recognize and bind to the protein TPSAB1. TPSAB1, also known as tryptase beta-1, is a serine protease primarily found in mast cells and plays a significant role in various physiological and pathological processes, including inflammation and allergic responses.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• TPSAB1

• Introduction
• Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

• Alternative Names
• Tryptase Alpha/Beta 1; Tryptase Alpha II; Tryptase Alpha-1; Tryptase Beta I; Tryptase-III; EC 3.4.21.59; Tryptase-I; Tryptase-1; TPSB1; TPS1

• Full Name
• Tryptase Alpha/Beta 1

• Gene ID
• 7177

• UniProt ID
• Q15661

• Sequence Similarities
• Belongs to the peptidase S1 family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Glycosylation at Asn132 and Asn233 ( NX_Q15661 [NX_Q15661-1] )
  Modification sites at PhosphoSitePlus ( Q15661 )
  Glycosylation from GlyConnect TRYB1_HUMAN (1861)
  Glycosylation from GlyGen (Q15661) 2 sites, 11 N-linked glycans (2 sites)

• Protein Refseq
• NP_003285.2

• Function
• Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
  May play a role in innate immunity.
  Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates.

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