H-2Dd/Human Immunodeficiency virus 1 Envelope glycoprotein (IPRRIRQGL) MHC Pentamer
CAT#: MHC-YC180
MHC multimers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a Pentamer of peptide/MHC complex with HIV1-derived peptide of IPRRIRQGL sequence covering 848-856 and H-2Dd molecule. The peptide/MHC pentamer provided here is unlabeled or fluorescent labeled such as Biotin, R-PE, APC. And all of them are available in 50, 150 or 500 tests.
Specifications
- Allele
- H-2Dd
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- Human Immunodeficiency virus 1 Envelope glycoprotein
- Antigen Species
- HIV1
- Peptide
- IPRRIRQGL
- Range
- 848-856
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CXCR4 and/or CCR5. Acts as a ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses. These interactions allow capture of viral particles at mucosal surfaces by these cells and subsequent transmission to permissive cells. HIV subverts the migration properties of dendritic cells to gain access to CD4+ T-cells in lymph nodes. Virus transmission to permissive T-cells occurs either in trans (without DCs infection, through viral capture and transmission), or in cis (following DCs productive infection, through the usual CD4-gp120 interaction), thereby inducing a robust infection. In trans infection, bound virions remain infectious over days and it is proposed that they are not degraded, but protected in non-lysosomal acidic organelles within the DCs close to the cell membrane thus contributing to the viral infectious potential during DCs' migration from the periphery to the lymphoid tissues. On arrival at lymphoid tissues, intact virions recycle back to DCs' cell surface allowing virus transmission to CD4+ T-cells.
- Alternative Names
- HIV1gp8; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; Envelope surface glycoprotein gp120
- Gene ID
- 155971
- UniProt ID
- P04578
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