H-2Dk/Polyoma virus Middle T protein (RRLGRTLLL) MHC Pentamer (CAT#: MHC-YF672)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed Polyoma virus middle T protein-derived peptide of RRLGRTLLL sequence covering 389-397 and H-2Dk molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
We require custom production
Specifications
- Allele
- H-2Dk
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- Middle T protein
- Antigen Species
- Polyoma virus
- Peptide
- RRLGRTLLL
- Range
- 389-397
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Plays a role in transformation by modulating the activities of cellular proteins involved in control of cell proliferation and by acting as a functional homolog of an activated tyrosine kinase-associated growth-factor receptor. Recruits upon association with host Ppp2/PP2A the Src tyrosine kinase components Src, Yes and Fyn, thereby activating their kinase activity. Activation of Shc1, Pclg1 and p85 mediate signal transduction pathways leading to cell cycle progression and cell division. MT plays also a role in regulation of early and late gene expression and in viral DNA replication.
- Alternative Names
- Middle T antigen; MT; MT-AG
- UniProt ID
- P03077
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