How can this MHC monomer be utilized in immunological research applications?

This MHC monomer can be used to generate tetramers or multimer complexes for flow cytometry analysis, allowing researchers to identify and quantify TRP2-specific CD8+ T cells. It is instrumental in studying T cell responses in melanoma immunotherapy research, vaccine development, and tumor immunology.

Is this monomer compatible with standard flow cytometry protocols?

Yes, once assembled into multimeric complexes like tetramers, the monomer can be used in standard flow cytometry protocols. It is conjugated with biotin, and there are other fluorochromes (such as PE, APC, or FITC) available for choice.

H-2Kb/Mouse TRP2 (SVYDFFVWL) MHC Monomer (CAT#: MHC-YF202)

This product is a MHC monomer of biotinylated peptide/MHC complex composed TRP2-derived peptide of SVYDFFVWL sequence covering 180-188 and H-2Kb molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.

Specific Inquiry

Custom Production

MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.

Peptide Sequence *:

Allele Requested *:

Antigen Species:

Antigen Molecule:

Sequence Position:

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Comments:

Disclaimer: Please note that the MHC reagents we offered have been produced with strict quality control (including gene sequencing, affinity purification, SDS-PAGE analysis, and verification of biotinylation), but many have not been confirmed to stain or activate specific T cells.

We require custom production

Datasheet
MSDS
COA

Datasheet

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Specifications

Allele
H-2Kb

Class
Class I

MHC Species
Mouse

Antigen
TRP2

Antigen Species
Mouse

Peptide
SVYDFFVWL

Range
180-188

Conjugate
Biotin

Application
MHC Multimer

Target

Alternative Names
TRP2

Gene ID
104042

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

Customer Reviews and Q&As

Customer Review Q&As

Flexible and Customizable

The ability to assemble the monomer into tetramers with fluorochromes of our choice has greatly enhanced our experimental flexibility. We've tailored our flow cytometry panels to our exact needs, which has improved the precision of our T cell analysis significantly.

Reliable Performance

We've used this monomer in numerous experiments, and it consistently performs well. The stability and quality of the product have ensured that our results are reproducible, which is essential for the credibility of our research findings.

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