H-2Kd/Listeria monocytogenes Listeriolysin O precursor (GYKDGNEYI) MHC Pentamer (CAT#: MHC-YC221)
MHC multimers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a Pentamer of peptide/MHC complex with Listeria-derived peptide of GYKDGNEYI sequence covering 91-99 and H-2Kd molecule. The peptide/MHC pentamer provided here is unlabeled or fluorescent labeled such as Biotin, R-PE, APC. And all of them are available in 50, 150 or 500 tests.
Specific Inquiry
Specifications
- Allele
- H-2Kd
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- Listeria monocytogenes Listeriolysin O precursor
- Antigen Species
- Listeria
- Peptide
- GYKDGNEYI
- Range
- 91-99
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Activity of listeriolysin O is regulated on multiple levels. It should be high in the phagosome, thereby allowing escape of the bacteria from the phagosomal compartment. Then, once inside the host cytosol, the activity must be controlled to prevent lysis of the host plasma membrane and loss of the intracellular environment. Multiple regulatory mechanisms include translational repression, which is required to minimize levels of listeriolysin O in the host cytosol. In addition, cytolytic activity is pH-dependent. Activity is high in the acidic environment of the phagosome and is turned off in the neutral pH of the cytosol. Listeriolysin O is also ubiquitinated and rapidly degraded by host proteasome in cytosol. The lytic activity is activated by reducing agents and suppressed by oxidation. Also inhibited by very low amounts of cholesterol.
- Alternative Names
- lmo0202
- Gene ID
- 987033
- UniProt ID
- P13128
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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