Anti-CD70 (h1F6)-vc-rachelmycin ADC (CAT#: ADC-073LCT)

• Antibody Overview
• 1F6 (Humanized Anti-CD70)

• Clone
• h1F6

• Antibody Isotype
• IgG1

• Linker
• VC (valine-citrulline)

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• CC-1065 (rachelmycin)

• Drug Class/Description
• CC-1065 is a kind of natural DNA alkylators and can be used as anti-tumor therapic agent because it can bind tightly to the minor groove of DNA and then react covalently with adenine bases.

• Introduction
• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;

• Gene ID
• 970

• UniProt ID
• P32970

• ADC-071LCT
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