Anti-CD70 (h1F6)-vc-MMAF ADC
CAT#: ADC-074LCT
This ADC product is composed of an anti-CD70 antibody (clone h1F6) conjuagated via a vc linker to MMAF (h1F6-vc-MMAF). It has demonstrated a response in Metastatic renal cell carcinoma (RCC) treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.



Specifications
- Antibody Overview
- 1F6 (Humanized Anti-CD70)
- Clone
- h1F6
- Linker
- VC (valine-citrulline)
- Linker Class/Description
- Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Gene ID
- 970
- UniProt ID
- P32970
Customer Review
There are currently no Customer reviews or questions for ADC-074LCT. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
See other products for "Clone h1F6"
- CAT
- Product Name
See other products for "CD70"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H76 | Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
TAB-335LC | Human Anti-CD70 Recombinant Antibody (TAB-335LC) | ELISA | Humanized IgG1, κ |
TAB-342LC | Human Anti-CD70 Recombinant Antibody (TAB-342LC) | FC | Humanized IgG |
TAB-343LC | Human Anti-CD70 Recombinant Antibody (TAB-343LC) | FC | Humanized IgG |
TAB-344LC | Human Anti-CD70 Recombinant Antibody (TAB-344LC) | FC, FuncS | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-336LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (Mb VLVH) | FC, ELISA | Human antibody |
TAB-337LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (Mb VHVL) | FC, ELISA | Human antibody |
TAB-338LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (VL-5-VH) | FC, ELISA | Human antibody |
TAB-339LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (VH-5-VL) | FC, ELISA | Human antibody |
TAB-340LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (VL-8-VH) | FC, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0095-LSX-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0095-LSX-F(E)) | ELISA, FC | Human Fab |
HPAB-0096-LSX-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0096-LSX-F(E)) | ELISA, FC | Human Fab |
HPAB-0097-LSX-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0097-LSX-F(E)) | ELISA, FC | Human Fab |
HPAB-0098-LSX-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0098-LSX-F(E)) | ELISA, FC | Human Fab |
HPAB-0099-LSX-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0099-LSX-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-M0487-YC-S(P) | Rat Anti-CD70 Recombinant Antibody (clone 4F2-12); scFv Fragment | FC | Rat scFv |
HPAB-AP584-YC-S(P) | Mouse Anti-CD70 Recombinant Antibody (clone m1F6); scFv Fragment | FC, ADCC, CDC, FuncS | Mouse scFv |
HPAB-AP585-YC-S(P) | Mouse Anti-CD70 Recombinant Antibody (clone c1F6); scFv Fragment | FC, ADCC, CDC, FuncS | Mouse scFv |
HPAB-AP586-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); scFv Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) scFv |
HPAB-AP587-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); scFv Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H76) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0468-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0468-WJ) | ELISA | Human IgG |
HPAB-0469-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0469-WJ) | ELISA | Human IgG |
HPAB-0470-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0470-WJ) | ELISA | Human IgG |
HPAB-0471-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0471-WJ) | ELISA | Human IgG |
HPAB-0472-WJ | Human Anti-CD70 Recombinant Antibody (HPAB-0472-WJ) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0924-YC123 | Human Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC123), CDC Enhanced | ELISA, Inhib, ADCC, ADCP, CDC | Antibody hexamer |
VS-0924-YC124 | Mouse Anti-CD70 Recombinant Antibody Hexamer (VS-0924-YC124), CDC Enhanced | FC, ADCC, CDC | Antibody hexamer |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY69 | CytoStream™ Rat Anti-CD70 Recombinant Antibody (clone FR70) | FC, Block, IF, Inhib | Rat IgG2b, kappa |
VS-0225-XY70 | CytoStream™ Mouse Anti-CD70 Recombinant Antibody (clone Ki-24) | FC | Mouse IgG3, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0325-FY72 | Human Anti-CD70 (clone 2H5) scFv-Fc Chimera | FC, ELISA, IHC, Block | Human IgG1, scFv-Fc |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC77 | Recombinant Anti-CD70 Vesicular Antibody, EV Displayed (VS-0425-YC77) | ELISA, FC, Neut, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY1215 | Anti-CD70 Immunohistochemistry Kit | IHC |
Popular Products
Application: WB, FC, IF, Inhib, ELISA, IHC
Application: ELISA, WB, FC
Application: Neut, FC, IHC-Fr, IP, BA
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, ELISA, FC, IHC, IP
Application: WB, ELISA, FC, IHC, IP
Application: SPR, Inhib, FuncS
Application: Neut, FC, IHC-Fr, IP, BA
Application: ELISA, WB, FC
Application: WB, FC, IF, Inhib, ELISA, IHC
Application: Neut, ELISA, IF, IP, FuncS, FC, IHC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.