Anti-CD70 (h1F6)-vc-MMAF ADC (CAT#: ADC-074LCT)

• Antibody Overview
• 1F6 (Humanized Anti-CD70)

• Clone
• h1F6

• Linker
• VC (valine-citrulline)

• Linker Class/Description
• Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAF (Monomethyl auristatin F)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

• Alternative Names
• CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;

• Gene ID
• 970

• UniProt ID
• P32970

• ADC-071LCT
• Anti-CD70 (h1F6)-vc-AFP ADC

• ADC-176LCT
• Anti-CD70(h1F6)-mc-vc-PBD ADC

• ADC-073LCT
• Anti-CD70 (h1F6)-vc-rachelmycin ADC

• ADC-078LCT
• Anti-CD70 (h1F6)-β-glucuronide-Camptothecin Analog ADC

• ADC-079LCT
• Anti-CD70 (h1F6)-β-glucuronide-CBI Minor Groove Binder ADC

• ADC-080LCT
• Anti-CD70 (h1F6)-β-glucuronide-MMAE ADC

• ADC-081LCT
• Anti-CD70 (h1F6)-β-glucuronide-MMAF ADC

• ADC-082LCT
• Anti-CD70 (h1F6)-β-glucuronide-potent doxorubicin ADC

• ADC-083LCT
• Anti-CD70 (h1F6)-maleimidebutaryl-vc-Duocarmycins ADC

• ADC-036LZY
• Anti-CD70 (clone h1F6)-mc-MMAF ADC

• ADC-051LZY
• Anti-CD70 (clone h1F6)-vc-PABC-MMAF ADC

• ADC-052LZY
• Anti-CD70 (clone h1F6)-MCC-DM1 ADC

• ADC-155LZY
• Anti-CD70 (clone h1F6 )-mc-vc-PABC-MMAE ADC

Select a product category from the dropdown menu below to view related products.