Anti-CD70 (clone h1F6)-MCC-DM1 ADC (CAT#: ADC-052LZY)
This ADC product is composed of an anti-CD70 antibody (clone h1F6) conjugated via MCC linker to DM1 (h1F6-MCC-DM1). It has demonstrated a response in renal cell carcinoma (RCC) treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
Specifications
- Antibody Overview
- Humanized Anti-CD70 IgG1, h1F6
- Clone
- h1F6
- Antibody Isotype
- IgG1
- Linker
- MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Gene ID
- 970
- UniProt ID
- P32970
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-336LC | Anti-Human CD70 Recombinant Antibody (Mb VLVH) | ELISA, FC, WB | Human antibody |
| TAB-337LC | Anti-Human CD70 Recombinant Antibody (Mb VHVL) | ELISA, FC, WB | Human antibody |
| TAB-339LC | Anti-Human CD70 Recombinant Antibody (VH-5-VL) | FC, WB | Human antibody |
| TAB-340LC | Anti-Human CD70 Recombinant Antibody (VL-8-VH) | FC, WB | Human antibody |
| TAB-341LC | Anti-Human CD70 Recombinant Antibody (VH-8-VL) | FC, WB | Human antibody |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-342LC | Human Anti-CD70 Recombinant Antibody (TAB-342LC) | FC | Humanized IgG |
| TAB-343LC | Human Anti-CD70 Recombinant Antibody (TAB-343LC) | FC | Humanized IgG |
| TAB-344LC | Human Anti-CD70 Recombinant Antibody (TAB-344LC) | FC, FuncS | Humanized antibody |
| TAB-335LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-335LC-S(P)) | ELISA | Humanized scFv |
| TAB-342LC-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (TAB-342LC-S(P)) | FC | Humanized scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1639MZ | Recombinant Mouse Anti-Human CD70 Antibody (clone CV70) | ELISA, FC, FuncS, IHC-Fr, IP | Mouse antibody |
| HPAB-0095-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0095-LSX) | ELISA, FC, ADCC, FuncS | Human IgG |
| HPAB-0096-LSX | Human Anti-CD70 Recombinant Antibody (HPAB-0096-LSX) | ELISA, FC, Block, FuncS | Human IgG |
| MOB-072LC | Human Anti-CD70 Recombinant Antibody (MOB-072LC) | ELISA, FC, FuncS | Human IgG |
| MOB-073LC | Mouse Anti-CD70 Recombinant Antibody (clone hCD70.21) | ELISA, FC, FuncS | Mouse IgG |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
| NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
| NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
| NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0487-YC-S(P) | Rat Anti-CD70 Recombinant Antibody (clone 4F2-12); scFv Fragment | FC | Rat scFv |
| HPAB-AP586-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HHLA); scFv Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) scFv |
| HPAB-AP587-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HELA); scFv Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) scFv |
| HPAB-AP588-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HJLA); scFv Fragment | FC, ADCC, CDC, FuncS | Humanized (mouse/human) scFv |
| HPAB-AP589-YC-S(P) | Human Anti-CD70 Recombinant Antibody (clone h1F6-HMLA); scFv Fragment | ELISA, Cyt, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0487-YC-F(E) | Rat Anti-CD70 Recombinant Antibody (clone 4F2-12); Fab Fragment | FC | Rat Fab |
| HPAB-0468-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0468-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0469-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0469-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0470-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0470-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0471-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0471-WJ-F(E)) | ELISA | Human Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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